Chronic graft-versus-host disease after hematopoietic cell transplantation presenting as an acute hepatitis

Arshad H. Malik, Robert H. Collins, M. Hossein Saboorian, William M. Lee

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A variety of illnesses involving the gut and liver follow hematopoietic cell transplantation (HCT). A 20 yr-old white male developed severe acute hepatitis 36 wk (day 252) after matched, unrelated, allogeneic HCT for chronic myelogenous leukemia (CML). Mild skin graft-versus-host disease (GVHD) had occurred at about 20 wk (day 140) after transplant. Liver biopsy showed bile duct injury and a diffuse lobular injury pattern most consistent with a GVHD variant and not reminiscent of drug-induced or viral hepatitis. No findings suggestive of herpesvirus, adenovirus, or varicella-zoster virus were found. High-dose steroids resulted in marked improvement of his liver enzyme levels. We report this patient as representing the acute hepatitic presentation of chronic GVHD of the liver.

Original languageEnglish (US)
Pages (from-to)588-590
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume96
Issue number2
DOIs
StatePublished - 2001

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Cell Transplantation
Graft vs Host Disease
Hepatitis
Liver
Human Herpesvirus 3
Herpesviridae
Wounds and Injuries
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Bile Ducts
Adenoviridae
Steroids
Transplants
Biopsy
Skin
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Chronic graft-versus-host disease after hematopoietic cell transplantation presenting as an acute hepatitis. / Malik, Arshad H.; Collins, Robert H.; Saboorian, M. Hossein; Lee, William M.

In: American Journal of Gastroenterology, Vol. 96, No. 2, 2001, p. 588-590.

Research output: Contribution to journalArticle

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