Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Simonetta Bandiera, C. Billie Bian, Yujin Hoshida, Thomas F. Baumert, Mirjam B. Zeisel

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) infection is one of the major causes of advanced liver disease and hepatocellular carcinoma (HCC) worldwide. While the knowledge about the molecular virology of HCV infection has markedly advanced, the molecular mechanisms of disease progression leading to fibrosis, cirrhosis and HCC are still unclear. Accumulating experimental and clinical studies indicate that HCV may drive hepatocarcinogenesis directly via its proteins or transcripts, and/or indirectly through induction of chronic liver inflammation. Despite the possibility to eradicate HCV infection through direct-acting antiviral treatment, the risk of HCC persists although specific biomarkers to estimate this risk are still missing. Thus, a better understanding of HCV-induced HCC and more physiological liver disease models are required to prevent cancer development.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalCurrent Opinion in Virology
Volume20
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

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Chronic Hepatitis C
Virus Diseases
Hepacivirus
Hepatocellular Carcinoma
Liver Diseases
Fibrosis
Virology
Antiviral Agents
Disease Progression
Biomarkers
Inflammation
Liver
Neoplasms
Proteins

ASJC Scopus subject areas

  • Virology

Cite this

Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma. / Bandiera, Simonetta; Billie Bian, C.; Hoshida, Yujin; Baumert, Thomas F.; Zeisel, Mirjam B.

In: Current Opinion in Virology, Vol. 20, 01.10.2016, p. 99-105.

Research output: Contribution to journalReview article

Bandiera, Simonetta ; Billie Bian, C. ; Hoshida, Yujin ; Baumert, Thomas F. ; Zeisel, Mirjam B. / Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma. In: Current Opinion in Virology. 2016 ; Vol. 20. pp. 99-105.
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