Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma

Simonetta Bandiera, C. Billie Bian, Yujin Hoshida, Thomas F. Baumert, Mirjam B. Zeisel

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Hepatitis C virus (HCV) infection is one of the major causes of advanced liver disease and hepatocellular carcinoma (HCC) worldwide. While the knowledge about the molecular virology of HCV infection has markedly advanced, the molecular mechanisms of disease progression leading to fibrosis, cirrhosis and HCC are still unclear. Accumulating experimental and clinical studies indicate that HCV may drive hepatocarcinogenesis directly via its proteins or transcripts, and/or indirectly through induction of chronic liver inflammation. Despite the possibility to eradicate HCV infection through direct-acting antiviral treatment, the risk of HCC persists although specific biomarkers to estimate this risk are still missing. Thus, a better understanding of HCV-induced HCC and more physiological liver disease models are required to prevent cancer development.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalCurrent Opinion in Virology
Volume20
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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