Chronic Intractable Epilepsy as the Only Symptom of Primary Brain Tumor

H. H. Morris, M. L. Estes, R. Gilmore, P. C. Van Ness, G. H. Barnett, J. Turnbull, P. Genton, A. Portera-Sanchez

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

We identified 39 patients with chronic epilepsy (seizures ≥2 years) proven to have primary brain tumors. These cases represent ∼12% of the surgery cases for epilepsy in the same period. Mean age of seizure onset was 13.2 years: mean duration before operation was 10.5 years. Thirty‐eight of 39 had normal neurologic examination. Twenty‐six tumors were temporal, 7 were frontal, 4 were parietal, and 2 were occipital. Nine of 26 (34.6%) of the temporal group had contralateral interictal EEG spikes. Pathology was 15 ganglioglioma, 13 low‐grade astrocytoma, 4 oligodendroglioma, 2 low‐grade mixed glioma, 1 pleomorphic xanthoastrocytoma, 2 dysembryoplastic neuroepithelial tumor, and 1 ependymoma. Postoperative seizure frequency (minimum follow‐up 6 months) ranged from 15 to 16 seizure‐free or auras only in patients with temporal tumors and total gross tumor removal (mean follow‐up 28 months) to 0 of 6 seizure‐free in patients with extratemporal tumors who underwent subtotal resections or biopsy.

Original languageEnglish (US)
Pages (from-to)1038-1043
Number of pages6
JournalEpilepsia
Volume34
Issue number6
DOIs
StatePublished - Nov 1993

Keywords

  • Brain tumor
  • Epilepsy
  • Neoplasms
  • Neurologic manifestations
  • Neurophysiology
  • Neurosurgery

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Morris, H. H., Estes, M. L., Gilmore, R., Van Ness, P. C., Barnett, G. H., Turnbull, J., Genton, P., & Portera-Sanchez, A. (1993). Chronic Intractable Epilepsy as the Only Symptom of Primary Brain Tumor. Epilepsia, 34(6), 1038-1043. https://doi.org/10.1111/j.1528-1157.1993.tb02131.x