Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson's disease

Patricia K. Sonsalla, Gail D. Zeevalk, Dwight C. German

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Animal models of Parkinson's disease (PD) that more closely exhibit the chronic neuropathology seen in the human condition are needed in order to reveal processes involved with progressive neurodegeneration and for testing potential interventions for retarding dopamine (DA) neuronal loss. Here we describe the recently developed chronic rat model of PD in which 1-methyl-4-phenylpyridinium ion (MPP+) is infused chronically into the lateral cerebral ventricle. We review features of this model that include loss of nigral DA neurons, swollen and abnormal mitochondria, striatal inclusion-like bodies and microgliosis. Advantages as well as limitations of the model are addressed.

Original languageEnglish (US)
JournalParkinsonism and Related Disorders
Volume14
Issue numberSUPPL.2
DOIs
StatePublished - Jul 2008

Fingerprint

1-Methyl-4-phenylpyridinium
Parkinson Disease
Corpus Striatum
Cerebral Ventricles
Lateral Ventricles
Dopaminergic Neurons
Inclusion Bodies
Substantia Nigra
Dopamine
Mitochondria
Animal Models
Neuropathology

Keywords

  • Chronic Parkinson's disease model
  • Dopamine
  • MPP
  • Neurodegeneration
  • Rat
  • Stereology

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology

Cite this

Chronic intraventricular administration of 1-methyl-4-phenylpyridinium as a progressive model of Parkinson's disease. / Sonsalla, Patricia K.; Zeevalk, Gail D.; German, Dwight C.

In: Parkinsonism and Related Disorders, Vol. 14, No. SUPPL.2, 07.2008.

Research output: Contribution to journalArticle

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