Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults

Manjula Kurella Tamura, Nicholas M. Pajewski, R. Nick Bryan, Daniel E. Weiner, Matthew Diamond, Peter Van Buren, Addison Taylor, Srinivasan Beddhu, Clive Rosendorff, Hesamoddin Jahanian, Greg Zaharchuk

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To determine the relation between markers of kidney disease - estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR) - with cerebral blood flow (CBF) and white matter volume (WMV) in hypertensive adults. Methods: We used baseline data collected from 665 nondiabetic hypertensive adults aged ≥50 years participating in the Systolic Blood Pressure Intervention Trial (SPRINT). We used arterial spin labeling to measure CBF and structural 3T images to segment tissue into normal and abnormal WMV. We used quantile regression to estimate the association between eGFR and UACR with CBF and abnormal WMV, adjusting for sociodemographic and clinical characteristics. Results: There were 218 participants (33%) with eGFR

Original languageEnglish (US)
Pages (from-to)1208-1216
Number of pages9
JournalNeurology
Volume86
Issue number13
DOIs
StatePublished - Mar 29 2016

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Cerebrovascular Circulation
Glomerular Filtration Rate
Chronic Renal Insufficiency
Albumins
Creatinine
Urine
Blood Pressure
Kidney Diseases
White Matter

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Kurella Tamura, M., Pajewski, N. M., Bryan, R. N., Weiner, D. E., Diamond, M., Van Buren, P., ... Zaharchuk, G. (2016). Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults. Neurology, 86(13), 1208-1216. https://doi.org/10.1212/WNL.0000000000002527

Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults. / Kurella Tamura, Manjula; Pajewski, Nicholas M.; Bryan, R. Nick; Weiner, Daniel E.; Diamond, Matthew; Van Buren, Peter; Taylor, Addison; Beddhu, Srinivasan; Rosendorff, Clive; Jahanian, Hesamoddin; Zaharchuk, Greg.

In: Neurology, Vol. 86, No. 13, 29.03.2016, p. 1208-1216.

Research output: Contribution to journalArticle

Kurella Tamura, M, Pajewski, NM, Bryan, RN, Weiner, DE, Diamond, M, Van Buren, P, Taylor, A, Beddhu, S, Rosendorff, C, Jahanian, H & Zaharchuk, G 2016, 'Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults', Neurology, vol. 86, no. 13, pp. 1208-1216. https://doi.org/10.1212/WNL.0000000000002527
Kurella Tamura, Manjula ; Pajewski, Nicholas M. ; Bryan, R. Nick ; Weiner, Daniel E. ; Diamond, Matthew ; Van Buren, Peter ; Taylor, Addison ; Beddhu, Srinivasan ; Rosendorff, Clive ; Jahanian, Hesamoddin ; Zaharchuk, Greg. / Chronic kidney disease, cerebral blood flow, and white matter volume in hypertensive adults. In: Neurology. 2016 ; Vol. 86, No. 13. pp. 1208-1216.
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