Chronic mitral regurgitation detected on cardiac MDCT: Differentiation between functional and valvular aetiologies

Ronan P. Killeen, Samer Arnous, Ramon Martos, Suhny Abbara, Martin Quinn, Jonathan D. Dodd

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To determine whether cardiac computed tomography (MDCT) can differentiate between functional and valvular aetiologies of chronic mitral regurgitation (MR) compared with echocardiography (TTE). Methods: Twenty-seven patients with functional or valvular MR diagnosed by TTE and 19 controls prospectively underwent cardiac MDCT. The morphological appearance of the mitral valve (MV) leaflets, MV geometry, MV leaflet angle, left ventricular (LV) sphericity and global/regional wall motion were analysed. The coronary arteries were evaluated for obstructive atherosclerosis. Results: All control and MR cases were correctly identified by MDCT. Significant differences were detected between valvular and control groups for anterior leaflet length (30±7 mm vs. 22±4 mm, P< 0.02) and thickness (3.0±1 mm vs. 2.2±1 mm, P<0.01). High-grade coronary stenosis was detected in all patients with functional MR compared with no controls (P<0.001). Significant differences in those with/without MV prolapse were detected in MV tent area (-1.0±0.6 mm vs. 1.3±0.9 mm, P<0.0001) and MV tent height (-0.7± 0.3 mm vs. 0.8±0.8 mm, P<0.0001). Posterior leaflet angle was significantly greater for functional MR (37.9±19.1° vs. 22.9±14°, P<0.018) and less for valvular MR (0.6±35.5° vs. 22.9±14°, P<0.017). Sensitivity, specificity, and positive and negative predictive values of MDCT were 100%, 95%, 96% and 100%. Conclusion: Cardiac MDCT allows the differentiation between functional and valvular causes of MR.

Original languageEnglish (US)
Pages (from-to)1886-1895
Number of pages10
JournalEuropean Radiology
Volume20
Issue number8
DOIs
StatePublished - Aug 2010

Fingerprint

Mitral Valve Insufficiency
Mitral Valve
Mitral Valve Prolapse
Coronary Stenosis
Echocardiography
Atherosclerosis
Coronary Vessels
Tomography
Sensitivity and Specificity
Control Groups

Keywords

  • Cardiomyopathy
  • Computed tomography
  • Coronary artery disease
  • Dilated/complications
  • Mitral valve insufficiency/aetiology
  • Mitral valve/anatomy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Chronic mitral regurgitation detected on cardiac MDCT : Differentiation between functional and valvular aetiologies. / Killeen, Ronan P.; Arnous, Samer; Martos, Ramon; Abbara, Suhny; Quinn, Martin; Dodd, Jonathan D.

In: European Radiology, Vol. 20, No. 8, 08.2010, p. 1886-1895.

Research output: Contribution to journalArticle

Killeen, Ronan P. ; Arnous, Samer ; Martos, Ramon ; Abbara, Suhny ; Quinn, Martin ; Dodd, Jonathan D. / Chronic mitral regurgitation detected on cardiac MDCT : Differentiation between functional and valvular aetiologies. In: European Radiology. 2010 ; Vol. 20, No. 8. pp. 1886-1895.
@article{38f67bf7b8644061ae392666879ad4b0,
title = "Chronic mitral regurgitation detected on cardiac MDCT: Differentiation between functional and valvular aetiologies",
abstract = "Objective: To determine whether cardiac computed tomography (MDCT) can differentiate between functional and valvular aetiologies of chronic mitral regurgitation (MR) compared with echocardiography (TTE). Methods: Twenty-seven patients with functional or valvular MR diagnosed by TTE and 19 controls prospectively underwent cardiac MDCT. The morphological appearance of the mitral valve (MV) leaflets, MV geometry, MV leaflet angle, left ventricular (LV) sphericity and global/regional wall motion were analysed. The coronary arteries were evaluated for obstructive atherosclerosis. Results: All control and MR cases were correctly identified by MDCT. Significant differences were detected between valvular and control groups for anterior leaflet length (30±7 mm vs. 22±4 mm, P< 0.02) and thickness (3.0±1 mm vs. 2.2±1 mm, P<0.01). High-grade coronary stenosis was detected in all patients with functional MR compared with no controls (P<0.001). Significant differences in those with/without MV prolapse were detected in MV tent area (-1.0±0.6 mm vs. 1.3±0.9 mm, P<0.0001) and MV tent height (-0.7± 0.3 mm vs. 0.8±0.8 mm, P<0.0001). Posterior leaflet angle was significantly greater for functional MR (37.9±19.1° vs. 22.9±14°, P<0.018) and less for valvular MR (0.6±35.5° vs. 22.9±14°, P<0.017). Sensitivity, specificity, and positive and negative predictive values of MDCT were 100{\%}, 95{\%}, 96{\%} and 100{\%}. Conclusion: Cardiac MDCT allows the differentiation between functional and valvular causes of MR.",
keywords = "Cardiomyopathy, Computed tomography, Coronary artery disease, Dilated/complications, Mitral valve insufficiency/aetiology, Mitral valve/anatomy",
author = "Killeen, {Ronan P.} and Samer Arnous and Ramon Martos and Suhny Abbara and Martin Quinn and Dodd, {Jonathan D.}",
year = "2010",
month = "8",
doi = "10.1007/s00330-010-1760-4",
language = "English (US)",
volume = "20",
pages = "1886--1895",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "8",

}

TY - JOUR

T1 - Chronic mitral regurgitation detected on cardiac MDCT

T2 - Differentiation between functional and valvular aetiologies

AU - Killeen, Ronan P.

AU - Arnous, Samer

AU - Martos, Ramon

AU - Abbara, Suhny

AU - Quinn, Martin

AU - Dodd, Jonathan D.

PY - 2010/8

Y1 - 2010/8

N2 - Objective: To determine whether cardiac computed tomography (MDCT) can differentiate between functional and valvular aetiologies of chronic mitral regurgitation (MR) compared with echocardiography (TTE). Methods: Twenty-seven patients with functional or valvular MR diagnosed by TTE and 19 controls prospectively underwent cardiac MDCT. The morphological appearance of the mitral valve (MV) leaflets, MV geometry, MV leaflet angle, left ventricular (LV) sphericity and global/regional wall motion were analysed. The coronary arteries were evaluated for obstructive atherosclerosis. Results: All control and MR cases were correctly identified by MDCT. Significant differences were detected between valvular and control groups for anterior leaflet length (30±7 mm vs. 22±4 mm, P< 0.02) and thickness (3.0±1 mm vs. 2.2±1 mm, P<0.01). High-grade coronary stenosis was detected in all patients with functional MR compared with no controls (P<0.001). Significant differences in those with/without MV prolapse were detected in MV tent area (-1.0±0.6 mm vs. 1.3±0.9 mm, P<0.0001) and MV tent height (-0.7± 0.3 mm vs. 0.8±0.8 mm, P<0.0001). Posterior leaflet angle was significantly greater for functional MR (37.9±19.1° vs. 22.9±14°, P<0.018) and less for valvular MR (0.6±35.5° vs. 22.9±14°, P<0.017). Sensitivity, specificity, and positive and negative predictive values of MDCT were 100%, 95%, 96% and 100%. Conclusion: Cardiac MDCT allows the differentiation between functional and valvular causes of MR.

AB - Objective: To determine whether cardiac computed tomography (MDCT) can differentiate between functional and valvular aetiologies of chronic mitral regurgitation (MR) compared with echocardiography (TTE). Methods: Twenty-seven patients with functional or valvular MR diagnosed by TTE and 19 controls prospectively underwent cardiac MDCT. The morphological appearance of the mitral valve (MV) leaflets, MV geometry, MV leaflet angle, left ventricular (LV) sphericity and global/regional wall motion were analysed. The coronary arteries were evaluated for obstructive atherosclerosis. Results: All control and MR cases were correctly identified by MDCT. Significant differences were detected between valvular and control groups for anterior leaflet length (30±7 mm vs. 22±4 mm, P< 0.02) and thickness (3.0±1 mm vs. 2.2±1 mm, P<0.01). High-grade coronary stenosis was detected in all patients with functional MR compared with no controls (P<0.001). Significant differences in those with/without MV prolapse were detected in MV tent area (-1.0±0.6 mm vs. 1.3±0.9 mm, P<0.0001) and MV tent height (-0.7± 0.3 mm vs. 0.8±0.8 mm, P<0.0001). Posterior leaflet angle was significantly greater for functional MR (37.9±19.1° vs. 22.9±14°, P<0.018) and less for valvular MR (0.6±35.5° vs. 22.9±14°, P<0.017). Sensitivity, specificity, and positive and negative predictive values of MDCT were 100%, 95%, 96% and 100%. Conclusion: Cardiac MDCT allows the differentiation between functional and valvular causes of MR.

KW - Cardiomyopathy

KW - Computed tomography

KW - Coronary artery disease

KW - Dilated/complications

KW - Mitral valve insufficiency/aetiology

KW - Mitral valve/anatomy

UR - http://www.scopus.com/inward/record.url?scp=77957955086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957955086&partnerID=8YFLogxK

U2 - 10.1007/s00330-010-1760-4

DO - 10.1007/s00330-010-1760-4

M3 - Article

C2 - 20309557

AN - SCOPUS:77957955086

VL - 20

SP - 1886

EP - 1895

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 8

ER -