Chronic nicotine attenuates phencyclidine-induced impulsivity in a mouse serial reaction time task

Daniel Scott, Jane R. Taylor

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Schizophrenia is a disorder characterized by positive, negative, and cognitive symptoms. While positive symptoms can be effectively treated with typical antipsychotic medication, which generally affects the dopaminergic system, negative and cognitive symptoms, including attentional deficits and impulsive behavior, are less sensitive to standard treatments. It has further been well documented that schizophrenic patients use tobacco products at a rate much higher than the general population, and this persists despite treatment. It has been argued this behavior may be a form of self-medication, to alleviate some symptoms of schizophrenia. It has further been posited that prefrontal glutamatergic hypofunction may underlie some aspects of schizophrenia, and in accordance with this model, systemic phencyclidine has been used to model the disease. We employed a modified 5-choice serial reaction time test, a paradigm that is often used to investigate many of the treatment-resistant symptoms of schizophrenia including impulsivity, selective attention, and sustained attention/cognitive vigilance, to determine the medicinal effects of nicotine. We demonstrate that chronic oral, but not acute injections of nicotine can selectively attenuate phencyclidine-induced increases in impulsivity without affecting other measures of attention. This suggests that nicotine use by schizophrenics may provide some relief of distinct symptoms that involve impulsive behaviors.

Original languageEnglish (US)
Pages (from-to)164-173
Number of pages10
JournalBehavioural Brain Research
Volume259
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

Fingerprint

Phencyclidine
Impulsive Behavior
Nicotine
Reaction Time
Schizophrenia
Neurobehavioral Manifestations
Self Medication
Tobacco Products
Antipsychotic Agents
Therapeutics
Injections
Population

Keywords

  • Impulsivity
  • Nicotine
  • Phencyclidine
  • Schizophrenia

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Chronic nicotine attenuates phencyclidine-induced impulsivity in a mouse serial reaction time task. / Scott, Daniel; Taylor, Jane R.

In: Behavioural Brain Research, Vol. 259, 01.02.2014, p. 164-173.

Research output: Contribution to journalArticle

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