Chronic suppression of acetyl-CoA carboxylase 1 in β-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism

Medicine & Life Sciences

• Acetyl-CoA Carboxylase 100%
• Insulin Secretion 73%
• Lipid Metabolism 70%
• Glucose 46%
• Pyruvic Acid 17%
• 2-furoic acid 16%
• Adenosine Diphosphate 16%
• 5-(tetradecyloxy)-2-furancarboxylic acid 16%
• Small Interfering RNA 13%
• Substrate Cycling 13%
• Adenosine Triphosphate 12%
• Glucokinase 11%
• Citric Acid Cycle 10%
• Glycogen 8%
• Islets of Langerhans 8%
• Dyslipidemias 8%
• Adenoviridae 8%
• Insulin Resistance 6%
• Obesity 5%
• Lipids 5%
• Cell Line 4%
• Messenger RNA 4%
• Enzymes 4%
• Proteins 3%
• Therapeutics 2%

Chemical Compounds

• Acetyl-CoA 90%
• Insulin Derivative 75%
• Pharmacological Metabolism 56%
• Glucose 54%
• Lipid 50%
• Small Interfering RNA 29%
• 5-(tetradecyloxy)-2-furoic Acid 22%
• ADP 21%
• Pyruvate 21%
• Tricarboxylic Acid 13%
• Glycogen 12%
• Enzyme Activity 8%
• Resistance 6%
• Oxidation Reaction 4%
• Protein 4%
• Acid 3%