Chylomicron triglyceride clearance

Comparison of three assessment methods

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Three indirect methods for assessing chylomicron-triglyceride clearance were compared in 12 normolipidemic men. Oral and intravenous fat tolerance tests and a duodenal fat perfusion were performed in each subject by standard methods. Mean values for postprandial lipemia (2.27 ± 1.8 mmol), Intralipid® half-life (13.7 ± 5.2 min), and chylomicron-triglyceride half-life (4.5 ± 2.6 min) were similar to corresponding values reported previously for normolipidemic men. The sample correlation coefficient (r) was 0.84 between oral and intravenous fat-tolerance tests, 0.84 between the oral fat-tolerance test and the duodenal-perfusion method, and 0.82 between the intravenous fat-tolerance and the duodenal perfusion methods. All three methods showed a strong correlation between chylomicron-triglyceride clearance and fasting triglyceride concentrations. These findings indicate that the oral and intravenous fat-tolerance tests and the duodenal-perfusion method yield qualitatively similar assessments of chylomicron-triglyceride clearance in normolipidemic men.

Original languageEnglish (US)
Pages (from-to)306-313
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume49
Issue number2
StatePublished - 1989

Fingerprint

Chylomicrons
chylomicrons
Triglycerides
Fats
triacylglycerols
mouth
lipids
Perfusion
half life
Half-Life
methodology
testing
hyperlipidemia
Hyperlipidemias
fasting
Fasting

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Chylomicron triglyceride clearance : Comparison of three assessment methods. / Cohen, J. C.

In: American Journal of Clinical Nutrition, Vol. 49, No. 2, 1989, p. 306-313.

Research output: Contribution to journalArticle

@article{1b9e03d5d0f745a5bc3683c3437dab66,
title = "Chylomicron triglyceride clearance: Comparison of three assessment methods",
abstract = "Three indirect methods for assessing chylomicron-triglyceride clearance were compared in 12 normolipidemic men. Oral and intravenous fat tolerance tests and a duodenal fat perfusion were performed in each subject by standard methods. Mean values for postprandial lipemia (2.27 ± 1.8 mmol), Intralipid{\circledR} half-life (13.7 ± 5.2 min), and chylomicron-triglyceride half-life (4.5 ± 2.6 min) were similar to corresponding values reported previously for normolipidemic men. The sample correlation coefficient (r) was 0.84 between oral and intravenous fat-tolerance tests, 0.84 between the oral fat-tolerance test and the duodenal-perfusion method, and 0.82 between the intravenous fat-tolerance and the duodenal perfusion methods. All three methods showed a strong correlation between chylomicron-triglyceride clearance and fasting triglyceride concentrations. These findings indicate that the oral and intravenous fat-tolerance tests and the duodenal-perfusion method yield qualitatively similar assessments of chylomicron-triglyceride clearance in normolipidemic men.",
author = "Cohen, {J. C.}",
year = "1989",
language = "English (US)",
volume = "49",
pages = "306--313",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "2",

}

TY - JOUR

T1 - Chylomicron triglyceride clearance

T2 - Comparison of three assessment methods

AU - Cohen, J. C.

PY - 1989

Y1 - 1989

N2 - Three indirect methods for assessing chylomicron-triglyceride clearance were compared in 12 normolipidemic men. Oral and intravenous fat tolerance tests and a duodenal fat perfusion were performed in each subject by standard methods. Mean values for postprandial lipemia (2.27 ± 1.8 mmol), Intralipid® half-life (13.7 ± 5.2 min), and chylomicron-triglyceride half-life (4.5 ± 2.6 min) were similar to corresponding values reported previously for normolipidemic men. The sample correlation coefficient (r) was 0.84 between oral and intravenous fat-tolerance tests, 0.84 between the oral fat-tolerance test and the duodenal-perfusion method, and 0.82 between the intravenous fat-tolerance and the duodenal perfusion methods. All three methods showed a strong correlation between chylomicron-triglyceride clearance and fasting triglyceride concentrations. These findings indicate that the oral and intravenous fat-tolerance tests and the duodenal-perfusion method yield qualitatively similar assessments of chylomicron-triglyceride clearance in normolipidemic men.

AB - Three indirect methods for assessing chylomicron-triglyceride clearance were compared in 12 normolipidemic men. Oral and intravenous fat tolerance tests and a duodenal fat perfusion were performed in each subject by standard methods. Mean values for postprandial lipemia (2.27 ± 1.8 mmol), Intralipid® half-life (13.7 ± 5.2 min), and chylomicron-triglyceride half-life (4.5 ± 2.6 min) were similar to corresponding values reported previously for normolipidemic men. The sample correlation coefficient (r) was 0.84 between oral and intravenous fat-tolerance tests, 0.84 between the oral fat-tolerance test and the duodenal-perfusion method, and 0.82 between the intravenous fat-tolerance and the duodenal perfusion methods. All three methods showed a strong correlation between chylomicron-triglyceride clearance and fasting triglyceride concentrations. These findings indicate that the oral and intravenous fat-tolerance tests and the duodenal-perfusion method yield qualitatively similar assessments of chylomicron-triglyceride clearance in normolipidemic men.

UR - http://www.scopus.com/inward/record.url?scp=0024508431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024508431&partnerID=8YFLogxK

M3 - Article

VL - 49

SP - 306

EP - 313

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 2

ER -