Cilia and flagella revealed: From flagellar assembly in Chlamydomonas to human obesity disorders

William J. Snell, Junmin Pan, Qian Wang

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations

Abstract

The recent identification in Chlamydomonas of the intraflagellar transport machinery that assembles cilia and flagella has triggered a renaissance of interest in these organelles that transcends studies on their well-characterized ability to move. New studies on several fronts have revealed that the machinery for flagellar assembly/disassembly is regulated by homologs of mitotic proteins, that cilia play essential roles in sensory transduction, and that mutations in cilia/basal body proteins are responsible for cilia-related human disorders from polycystic kidney disease to a syndrome associated with obesity, hypertension, and diabetes.

Original languageEnglish (US)
Pages (from-to)693-697
Number of pages5
JournalCell
Volume117
Issue number6
DOIs
StatePublished - Jun 11 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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