Cilia in autophagy and cancer

Muqing Cao, Qing Zhong

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Cancer cells are distinguished from normal cells by increased proliferation and metabolism, loss of polarity control, and the potential to invade other tissues of the body. As hubs of signaling transduction, primary cilia have been linked to diverse developmental and degenerative disorders. Interestingly, loss of cilia has been observed in multiple malignant tumors, suggesting a potential suppressive role of cilia in cancer development. More recently, emerging studies began to unveil the bidirectional interaction of cilia and autophagy, a basic cellular clearance and recycling mechanism to regulate cell homeostasis. Here, we summarize the interplay between cilia and autophagy and discuss the roles of cilia in both autophagy and cancer.

Original languageEnglish (US)
Article number4
JournalCilia
Volume5
Issue number1
DOIs
StatePublished - Feb 3 2016

Keywords

  • Autophagy
  • Cancer
  • Cell cycle
  • Cilia
  • Cilia-related signaling

ASJC Scopus subject areas

  • Cell Biology

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