Cilia-like beating of active microtubule bundles

Timothy Sanchez, David Welch, Daniela Nicastro, Zvonimir Dogic

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

The mechanism that drives the regular beating of individual cilia and flagella, as well as dense ciliary fields, remains unclear. We describe a minimal model system, composed of microtubules and molecular motors, which self-assemble into active bundles exhibiting beating patterns reminiscent of those found in eukaryotic cilia and flagella. These observations suggest that hundreds of molecular motors, acting within an elastic microtubule bundle, spontaneously synchronize their activity to generate large-scale oscillations. Furthermore, we also demonstrate that densely packed, actively bending bundles spontaneously synchronize their beating patterns to produce collective behavior similar to metachronal waves observed in ciliary fields. The simple in vitro system described here could provide insights into beating of isolated eukaryotic cilia and flagella, as well as their synchronization in dense ciliary fields.

Original languageEnglish (US)
Pages (from-to)456-459
Number of pages4
JournalScience
Volume333
Issue number6041
DOIs
StatePublished - Jul 22 2011

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Flagella
Cilia
Microtubules

ASJC Scopus subject areas

  • General

Cite this

Cilia-like beating of active microtubule bundles. / Sanchez, Timothy; Welch, David; Nicastro, Daniela; Dogic, Zvonimir.

In: Science, Vol. 333, No. 6041, 22.07.2011, p. 456-459.

Research output: Contribution to journalArticle

Sanchez, T, Welch, D, Nicastro, D & Dogic, Z 2011, 'Cilia-like beating of active microtubule bundles', Science, vol. 333, no. 6041, pp. 456-459. https://doi.org/10.1126/science.1203963
Sanchez, Timothy ; Welch, David ; Nicastro, Daniela ; Dogic, Zvonimir. / Cilia-like beating of active microtubule bundles. In: Science. 2011 ; Vol. 333, No. 6041. pp. 456-459.
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