Cilia, tubby mice, and obesity

Saikat Mukhopadhyay, Peter K. Jackson

Research output: Contribution to journalComment/debate

7 Scopus citations

Abstract

Primary cilia have been previously linked to the central regulation of satiety. The tubby mouse is characterized by maturity-onset obesity and blindness. A recent paper demonstrates molecular defects in trafficking of ciliary GPCRs in the central neurons of tubby mice, underscoring the role of ciliary signaling in the pathogenesis of this monogenic obesity syndrome.Please see related Research article by Li et al., http://www.ciliajournal.com/content/1/1/21.

Original languageEnglish (US)
Article number1
JournalCilia
Volume2
Issue number1
DOIs
StatePublished - Jan 2013

ASJC Scopus subject areas

  • Cell Biology

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