Ciprofloxacin 0.3% + dexamethasone 0.1% for the treatment for otitis media

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Ciprofloxacin 0.3% with dexamethasone 0.1% (ciprofloxacin/dexamethasone) is an ototopical preparation for acute otitis externa, otorrhea with tympanostomy tubes, and is frequently used to treat chronic suppurative otitis media (CSOM). The advantage of topical therapy is the ability to deliver higher concentration of antibiotics to the treatment site when compared with oral or parenteral antibiotics. The delivery of a high concentration of antibiotics significantly decreases treatment failure and makes the development of resistant organisms unlikely. Previous ototopical preparations contained antibiotics such as aminoglycosides that are known to be ototoxic making treatment of otic infections without an intact tympanic membrane difficulty. Areas covered: A literature search of PubMed was performed as the basis for a literature-based discussion on the clinical efficacy of ciprofloxacin/dexamethasone compared to oral antibiotics and ototopical therapy without a steroid component. The potential ototoxicity of ototopical therapies is discussed, including evidence demonstrating the lack of ototoxicity of fluoroquinolone and dexamethasone containing drops. Expert opinion: Because multiple studies have demonstrated that fluoroquinolones are not ototoxic, fluoroquinolone ototopical drops should be a first-line treatment for otorrhea without an intact membrane. The addition of dexamethasone 0.1% to ciprofloxacin 0.3% has been shown to decrease granulation tissue, improve clinical cure and achieve greater rates of bacterial eradication when compared to ciprofloxacin 0.3% alone.

Original languageEnglish (US)
Pages (from-to)2399-2405
Number of pages7
JournalExpert Opinion on Pharmacotherapy
Volume14
Issue number17
DOIs
StatePublished - Dec 2013

Fingerprint

Otitis Media
Ciprofloxacin
Dexamethasone
Anti-Bacterial Agents
Fluoroquinolones
Middle Ear Ventilation
Suppurative Otitis Media
Otitis Externa
Tympanic Membrane
Granulation Tissue
Expert Testimony
Aminoglycosides
Treatment Failure
PubMed
Ear
Therapeutics
Steroids
Membranes
Infection

Keywords

  • Chronic suppurative otitis media
  • Otitis media
  • Steroid
  • Topical therapy
  • Tympanostomy tube otorrhea

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Ciprofloxacin 0.3% + dexamethasone 0.1% for the treatment for otitis media. / Kutz, Joe Walter; Roland, Peter S.; Lee, Kenneth H.

In: Expert Opinion on Pharmacotherapy, Vol. 14, No. 17, 12.2013, p. 2399-2405.

Research output: Contribution to journalArticle

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