Circadian fluctuations of cAMP content in the suprachiasmatic nucleus and the anterior hypothalamus of the rat

Shin Yamazaki, Mutsumi Maruyama, Felino R A Cagampang, Shin Ichi T Inouye

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Signal transduction by second messengers has long been hypothesized to be involved in the circadian system in the suprachiasmatic nucleus (SCN) of the mammalian brain. The present study reports that the concentration of adenosine-3′,5′-monophosphate (cyclic AMP or cAMP) in the SCN region exhibited a circadian fluctuation with two peaks during a day under constant conditions. While a sharp peak at around the end of the subjective night was observed only in the SCN region, the other peak in the late subjective day was also found in the anterior hypothalamic area. The distinct cAMP peak at the late subjective night contrasts with the daytime peaks in electrical and metabolic activity rhythms of the SCN.

Original languageEnglish (US)
Pages (from-to)329-331
Number of pages3
JournalBrain Research
Volume651
Issue number1-2
DOIs
StatePublished - Jul 18 1994

Keywords

  • Circadian rhythm
  • Enzyme immunoassay
  • Rat
  • Suprachiasmatic nucleus
  • cAMP

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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