Circadian rhythm of neuropeptide y-like immunoreactivity in the iris-ciliary body of the rat

Yasumasa Otori, Felino Ramon A Cagampang, Shin Yamazaki, Shin Ichi T Inouye, Tomiya Mano, Yasuo Tano

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Neuropeptide Y (NPY)-like immunoreactivity (LI) in the irisciliary body of rats kept under constant darkness (DD) and in 12 h light-12 h dark cycle (LD) was determined by enzyme immunoassay. NPY-LI contents in the iris-ciliary body were found to oscillate in circadian fashion under DD and LD conditions, with a peak at about circadian time 12 (CT 12) and a trough at around CT 0. Unilateral superior cervical ganglionectomy caused a significant decrease in NPY-LI levels in the sympathectomized eye compare to the contralateral intact eye, independent of lighting phase. These results suggest the presence of an endogenous circadian rhythm in NPY-LI content in the rat iris-ciliary body, and the possible involvement of a sympathetic input from the superior cervical ganglion.

Original languageEnglish (US)
Pages (from-to)803-807
Number of pages5
JournalCurrent Eye Research
Volume12
Issue number9
DOIs
StatePublished - 1993

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Ciliary Body
Neuropeptide Y
Iris
Circadian Rhythm
Neuropeptides
Ganglionectomy
Superior Cervical Ganglion
Darkness
Lighting
Immunoenzyme Techniques
Light

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Circadian rhythm of neuropeptide y-like immunoreactivity in the iris-ciliary body of the rat. / Otori, Yasumasa; Cagampang, Felino Ramon A; Yamazaki, Shin; Inouye, Shin Ichi T; Mano, Tomiya; Tano, Yasuo.

In: Current Eye Research, Vol. 12, No. 9, 1993, p. 803-807.

Research output: Contribution to journalArticle

Otori, Yasumasa ; Cagampang, Felino Ramon A ; Yamazaki, Shin ; Inouye, Shin Ichi T ; Mano, Tomiya ; Tano, Yasuo. / Circadian rhythm of neuropeptide y-like immunoreactivity in the iris-ciliary body of the rat. In: Current Eye Research. 1993 ; Vol. 12, No. 9. pp. 803-807.
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AU - Mano, Tomiya

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