TY - JOUR
T1 - Circadian rhythms of cortisol during alcohol withdrawal
AU - Risher-Flowers, D.
AU - Adinoff, B.
AU - Ravitz, B.
AU - Bone, G. H A
AU - Martin, P. R.
AU - Nutt, D.
AU - Linnoila, M.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1988/3/1
Y1 - 1988/3/1
N2 - The authors have investigated the function of the hypothalamic-pituitary-adrenocortical (HPA) axis during and after withdrawal from alcohol. 24 hour rhythms of cortisol were abnormal in that elevated levels were seen throughout the day in patients with moderate to severe, but not mild, withdrawal. This abnormality of circadian secretion of cortisol, which is similar to that seen in Cushing’s syndrome and post-operative trauma, returned to normal after a period of one week of abstinence on their in-patient ward. Such excessive secretion of cortisol may explain some of the complications of chronic alcoholism.
AB - The authors have investigated the function of the hypothalamic-pituitary-adrenocortical (HPA) axis during and after withdrawal from alcohol. 24 hour rhythms of cortisol were abnormal in that elevated levels were seen throughout the day in patients with moderate to severe, but not mild, withdrawal. This abnormality of circadian secretion of cortisol, which is similar to that seen in Cushing’s syndrome and post-operative trauma, returned to normal after a period of one week of abstinence on their in-patient ward. Such excessive secretion of cortisol may explain some of the complications of chronic alcoholism.
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U2 - 10.1300/J251v07n03_06
DO - 10.1300/J251v07n03_06
M3 - Article
C2 - 3223434
AN - SCOPUS:0024274767
SN - 0270-3106
VL - 7
SP - 37
EP - 41
JO - Advances in Alcohol and Substance Abuse
JF - Advances in Alcohol and Substance Abuse
IS - 3-4
ER -