Circadian rhythms of serum renin activity and serum corticosterone, prolactin, and aldosterone concentrations in the male rat on normal and low sodium diets

C. Gomez-Sanchez, O. B. Holland, J. R. Higgins, D. C. Kem, Norman M Kaplan

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Abstract

To investigate the control of aldosterone secretion, non stress levels of serum aldosterone, corticosterone, and prolactin, and renin activity were determined at 4 h intervals during 24 h light dark cycles in adult male rats on regular and low sodium diets. Circadian rhythms of plasma aldosterone, prolactin, and corticosterone concentrations and of serum renin activity were demonstrated during a regular sodium diet. When the rats were on a low sodium diet, a circadian rhythm of serum corticosterone and aldosterone concentration was observed, but there was no circadian variation in serum renin activity or in serum prolactin concentration. Serum aldosterone concentration correlated with serum corticosterone concentration (r=0.48) and serum renin activity (r=0.28) during a regular sodium diet and with serum renin activity (r=0.36) during a low sodium diet. Serum prolactin concentration did not increase with sodium depletion and did not correlate with serum aldosterone concentration or serum osmolality. These data are compatible with a role for renin and ACTH, but not for prolactin, in the modulation of aldosterone secretion in the rat.

Original languageEnglish (US)
Pages (from-to)567-572
Number of pages6
JournalEndocrinology
Volume99
Issue number2
StatePublished - 1976

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Sodium-Restricted Diet
Corticosterone
Circadian Rhythm
Aldosterone
Renin
Prolactin
Serum
Sodium
Diet
Photoperiod
Adrenocorticotropic Hormone
Osmolar Concentration

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Circadian rhythms of serum renin activity and serum corticosterone, prolactin, and aldosterone concentrations in the male rat on normal and low sodium diets. / Gomez-Sanchez, C.; Holland, O. B.; Higgins, J. R.; Kem, D. C.; Kaplan, Norman M.

In: Endocrinology, Vol. 99, No. 2, 1976, p. 567-572.

Research output: Contribution to journalArticle

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abstract = "To investigate the control of aldosterone secretion, non stress levels of serum aldosterone, corticosterone, and prolactin, and renin activity were determined at 4 h intervals during 24 h light dark cycles in adult male rats on regular and low sodium diets. Circadian rhythms of plasma aldosterone, prolactin, and corticosterone concentrations and of serum renin activity were demonstrated during a regular sodium diet. When the rats were on a low sodium diet, a circadian rhythm of serum corticosterone and aldosterone concentration was observed, but there was no circadian variation in serum renin activity or in serum prolactin concentration. Serum aldosterone concentration correlated with serum corticosterone concentration (r=0.48) and serum renin activity (r=0.28) during a regular sodium diet and with serum renin activity (r=0.36) during a low sodium diet. Serum prolactin concentration did not increase with sodium depletion and did not correlate with serum aldosterone concentration or serum osmolality. These data are compatible with a role for renin and ACTH, but not for prolactin, in the modulation of aldosterone secretion in the rat.",
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AU - Holland, O. B.

AU - Higgins, J. R.

AU - Kem, D. C.

AU - Kaplan, Norman M

PY - 1976

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N2 - To investigate the control of aldosterone secretion, non stress levels of serum aldosterone, corticosterone, and prolactin, and renin activity were determined at 4 h intervals during 24 h light dark cycles in adult male rats on regular and low sodium diets. Circadian rhythms of plasma aldosterone, prolactin, and corticosterone concentrations and of serum renin activity were demonstrated during a regular sodium diet. When the rats were on a low sodium diet, a circadian rhythm of serum corticosterone and aldosterone concentration was observed, but there was no circadian variation in serum renin activity or in serum prolactin concentration. Serum aldosterone concentration correlated with serum corticosterone concentration (r=0.48) and serum renin activity (r=0.28) during a regular sodium diet and with serum renin activity (r=0.36) during a low sodium diet. Serum prolactin concentration did not increase with sodium depletion and did not correlate with serum aldosterone concentration or serum osmolality. These data are compatible with a role for renin and ACTH, but not for prolactin, in the modulation of aldosterone secretion in the rat.

AB - To investigate the control of aldosterone secretion, non stress levels of serum aldosterone, corticosterone, and prolactin, and renin activity were determined at 4 h intervals during 24 h light dark cycles in adult male rats on regular and low sodium diets. Circadian rhythms of plasma aldosterone, prolactin, and corticosterone concentrations and of serum renin activity were demonstrated during a regular sodium diet. When the rats were on a low sodium diet, a circadian rhythm of serum corticosterone and aldosterone concentration was observed, but there was no circadian variation in serum renin activity or in serum prolactin concentration. Serum aldosterone concentration correlated with serum corticosterone concentration (r=0.48) and serum renin activity (r=0.28) during a regular sodium diet and with serum renin activity (r=0.36) during a low sodium diet. Serum prolactin concentration did not increase with sodium depletion and did not correlate with serum aldosterone concentration or serum osmolality. These data are compatible with a role for renin and ACTH, but not for prolactin, in the modulation of aldosterone secretion in the rat.

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