Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Caveolae are a subset of lipid rafts that are prevalent on the plasma membrane of endothelial cells. They compartmentalize signal transduction molecules which regulate multiple endothelial functions including the production of nitric oxide (NO) by the caveolae resident enzyme endothelial NO synthase (eNOS). Recent studies have demonstrated that circulating factors known to modify cardiovascular disease risk regulate signaling in endothelial cell caveolae. In particular, high density lipoprotein (HDL) maintains the lipid environment in caveolae, thereby promoting the retention and function of eNOS in the domain, and it also causes direct activation of eNOS via scavenger receptor type BI (SR-BI)-induced kinase signaling. Estrogen binding to estrogen receptors (ER) in caveolae also activates eNOS, and this occurs through G protein and kinase activation. Discrete domains within SR-BI and ER mediating signal initiation in caveolae have been identified. Counteracting the promodulatory actions of HDL and estrogen, C-reactive protein (CRP) antagonizes eNOS through FcγRIIB and PP2A, which dephosphorylates and inactivates the enzyme. The endothelial cell functions modified by these processes include the regulation of monocyte adhesion and endothelial cell migration. Thus, signaling events in caveolae invoked by known circulating cardiovascular disease risk factors have major impact on endothelial cell phenotypes of importance to cardiovascular health and disease.

Original languageEnglish (US)
Pages (from-to)31-41
Number of pages11
JournalCardiovascular Research
Volume70
Issue number1
DOIs
StatePublished - Apr 1 2006

Fingerprint

Caveolae
Cardiovascular Diseases
Endothelial Cells
Nitric Oxide Synthase
Scavenger Receptors
HDL Lipoproteins
Estrogen Receptors
Estrogens
Lipids
Cyclic GMP-Dependent Protein Kinases
Nitric Oxide Synthase Type III
Enzymes
C-Reactive Protein
Cell Movement
Monocytes
Signal Transduction
Nitric Oxide
Phosphotransferases
Cell Membrane
Phenotype

Keywords

  • C-reactive protein
  • Caveolae
  • Endothelium
  • Estrogen
  • High density lipoprotein
  • Nitric oxide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Circulating cardiovascular disease risk factors and signaling in endothelial cell caveolae. / Mineo, Chieko; Shaul, Philip W.

In: Cardiovascular Research, Vol. 70, No. 1, 01.04.2006, p. 31-41.

Research output: Contribution to journalArticle

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