Circulating opsonic fibronectin and peripheral blood neutrophils’ activity in acute burns

Marek Dobke, Georgina Pearson, Cheryl Roberts, Betty Germany, Ellen Heck, Bettie Sue Masters, Charles R. Baxter

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Recent experimental and clinical evidence has suggested that circulating fibronectin plays an important role as a nonspecific opsonin in the phagocytosis of some bacteria The effect of circulating fibronectin levels on leukocyte phagocytosis was determined in a serial study of 20 burn patients (mean TBSA 56% range 32%–84%) and in 24 healthy donors. The metabolic activity of per-ipheral blood leukocytes as reflected by oxygen consumption after stimulation with preopsonized zymosan correlated with fibronectin levels (rocket immunoelectrophore-sis) in healthy donors (r = 0.77 P<0.05). The results showed a decrease of fibronectin level in burned patients’ serum with parallel decreased leukocyte oxygen consumption (r = 0.95 P<0.005 for the first three days postburn). Profound decrease of both values was observed especially during the septic episodes. Decrease of leukocytes’ oxygen consumption when incubated in fibronectin-depleted serum (affinity chromatography) additionally suggests participation of fibronectin in the opsonization processes of some target particles.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalJournal of Burn Care and Rehabilitation
Volume4
Issue number5
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Surgery
  • Nursing(all)
  • Emergency Medicine
  • Rehabilitation
  • Health Professions(all)

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    Dobke, M., Pearson, G., Roberts, C., Germany, B., Heck, E., Masters, B. S., & Baxter, C. R. (1983). Circulating opsonic fibronectin and peripheral blood neutrophils’ activity in acute burns. Journal of Burn Care and Rehabilitation, 4(5), 337-343. https://doi.org/10.1097/00004630-198309000-00003