Circulating opsonic fibronectin and peripheral blood neutrophils’ activity in acute burns

Marek Dobke, Georgina Pearson, Cheryl Roberts, Betty Germany, Ellen Heck, Bettie Sue Masters, Charles R. Baxter

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recent experimental and clinical evidence has suggested that circulating fibronectin plays an important role as a nonspecific opsonin in the phagocytosis of some bacteria The effect of circulating fibronectin levels on leukocyte phagocytosis was determined in a serial study of 20 burn patients (mean TBSA 56% range 32%–84%) and in 24 healthy donors. The metabolic activity of per-ipheral blood leukocytes as reflected by oxygen consumption after stimulation with preopsonized zymosan correlated with fibronectin levels (rocket immunoelectrophore-sis) in healthy donors (r = 0.77 P<0.05). The results showed a decrease of fibronectin level in burned patients’ serum with parallel decreased leukocyte oxygen consumption (r = 0.95 P<0.005 for the first three days postburn). Profound decrease of both values was observed especially during the septic episodes. Decrease of leukocytes’ oxygen consumption when incubated in fibronectin-depleted serum (affinity chromatography) additionally suggests participation of fibronectin in the opsonization processes of some target particles.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalJournal of Burn Care and Rehabilitation
Volume4
Issue number5
StatePublished - 1983

Fingerprint

Burns
Fibronectins
Neutrophils
Leukocytes
Oxygen Consumption
Phagocytosis
Tissue Donors
Opsonin Proteins
Zymosan
Serum
Affinity Chromatography
Bacteria

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Clinical Psychology
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Emergency Medicine
  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)

Cite this

Dobke, M., Pearson, G., Roberts, C., Germany, B., Heck, E., Masters, B. S., & Baxter, C. R. (1983). Circulating opsonic fibronectin and peripheral blood neutrophils’ activity in acute burns. Journal of Burn Care and Rehabilitation, 4(5), 337-343.

Circulating opsonic fibronectin and peripheral blood neutrophils’ activity in acute burns. / Dobke, Marek; Pearson, Georgina; Roberts, Cheryl; Germany, Betty; Heck, Ellen; Masters, Bettie Sue; Baxter, Charles R.

In: Journal of Burn Care and Rehabilitation, Vol. 4, No. 5, 1983, p. 337-343.

Research output: Contribution to journalArticle

Dobke, M, Pearson, G, Roberts, C, Germany, B, Heck, E, Masters, BS & Baxter, CR 1983, 'Circulating opsonic fibronectin and peripheral blood neutrophils’ activity in acute burns', Journal of Burn Care and Rehabilitation, vol. 4, no. 5, pp. 337-343.
Dobke M, Pearson G, Roberts C, Germany B, Heck E, Masters BS et al. Circulating opsonic fibronectin and peripheral blood neutrophils’ activity in acute burns. Journal of Burn Care and Rehabilitation. 1983;4(5):337-343.
Dobke, Marek ; Pearson, Georgina ; Roberts, Cheryl ; Germany, Betty ; Heck, Ellen ; Masters, Bettie Sue ; Baxter, Charles R. / Circulating opsonic fibronectin and peripheral blood neutrophils’ activity in acute burns. In: Journal of Burn Care and Rehabilitation. 1983 ; Vol. 4, No. 5. pp. 337-343.
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