Abstract
Somatostatin perfused in canine pancreases at 10 to 20 picograms per milliliter or 10 to 20 percent of the pancreatic vein somatostatin concentration inhibited insulin and glucagon secretion. This suggests that the high local concentration of endogenous somatostatin is not in contact with somatostatin receptors of the islets. The integrity of this separation may determine the sensitivity of islet cells to circulating somatostatin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 477-478 |
| Number of pages | 2 |
| Journal | Science |
| Volume | 218 |
| Issue number | 4571 |
| State | Published - 1982 |
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Cite this
Circulating somatostatin acts on the islets of Langerhans by way of a somatostatin-poor compartment. / Kawai, Koichi; Ipp, Eli; Orci, Lelio; Perrelet, Alain; Unger, Roger H.
In: Science, Vol. 218, No. 4571, 1982, p. 477-478.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Circulating somatostatin acts on the islets of Langerhans by way of a somatostatin-poor compartment
AU - Kawai, Koichi
AU - Ipp, Eli
AU - Orci, Lelio
AU - Perrelet, Alain
AU - Unger, Roger H
PY - 1982
Y1 - 1982
N2 - Somatostatin perfused in canine pancreases at 10 to 20 picograms per milliliter or 10 to 20 percent of the pancreatic vein somatostatin concentration inhibited insulin and glucagon secretion. This suggests that the high local concentration of endogenous somatostatin is not in contact with somatostatin receptors of the islets. The integrity of this separation may determine the sensitivity of islet cells to circulating somatostatin.
AB - Somatostatin perfused in canine pancreases at 10 to 20 picograms per milliliter or 10 to 20 percent of the pancreatic vein somatostatin concentration inhibited insulin and glucagon secretion. This suggests that the high local concentration of endogenous somatostatin is not in contact with somatostatin receptors of the islets. The integrity of this separation may determine the sensitivity of islet cells to circulating somatostatin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019919726&partnerID=8YFLogxK
M3 - Article
C2 - 6126931
AN - SCOPUS:0019919726
VL - 218
SP - 477
EP - 478
JO - Science
JF - Science
SN - 0036-8075
IS - 4571
ER -