Circulating somatostatin acts on the islets of Langerhans by way of a somatostatin-poor compartment

Koichi Kawai; Eli Ipp; Lelio Orci; Alain Perrelet; Roger H Unger

doi:10.1126/science.6126931

Circulating somatostatin acts on the islets of Langerhans by way of a somatostatin-poor compartment

Koichi Kawai, Eli Ipp, Lelio Orci, Alain Perrelet, Roger H Unger

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Somatostatin perfused in canine pancreases at 10 to 20 picograms per milliliter or 10 to 20 percent of the pancreatic vein somatostatin concentration inhibited insulin and glucagon secretion. This suggests that the high local concentration of endogenous somatostatin is not in contact with somatostatin receptors of the islets. The integrity of this separation may determine the sensitivity of islet cells to circulating somatostatin.

Original language	English (US)
Pages (from-to)	477-478
Number of pages	2
Journal	Science
Volume	218
Issue number	4571
DOIs	https://doi.org/10.1126/science.6126931
State	Published - Jan 1 1982

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abstract = "Somatostatin perfused in canine pancreases at 10 to 20 picograms per milliliter or 10 to 20 percent of the pancreatic vein somatostatin concentration inhibited insulin and glucagon secretion. This suggests that the high local concentration of endogenous somatostatin is not in contact with somatostatin receptors of the islets. The integrity of this separation may determine the sensitivity of islet cells to circulating somatostatin.",

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