Circulatory Antigen Processing by Mucosal Dendritic Cells Controls CD8+ T Cell Activation

Sun Young Chang, Joo Hye Song, Bayasi Guleng, Carmen Alonso Cotoner, Seiji Arihiro, Yun Zhao, Hao Sen Chiang, Michael O'Keeffe, Gongxian Liao, Christopher L. Karp, Mi Na Kweon, Arlene H. Sharpe, Atul Bhan, Cox Terhorst, Hans Christian Reinecker

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Circulatory antigens transit through the small intestine via the fenestrated capillaries in the lamina propria prior to entering into the draining lymphatics. But whether or how this process controls mucosal immune responses remains unknown. Here we demonstrate that dendritic cells (DCs) of the lamina propria can sample and process both circulatory and luminal antigens. Surprisingly, antigen cross-presentation by resident CX3CR1+ DCs induced differentiation of precursor cells into CD8+ T cells that expressed interleukin-10 (IL-10), IL-13, and IL-9 and could migrate into adjacent compartments. We conclude that lamina propria CX3CR1+ DCs facilitate the surveillance of circulatory antigens and act as a conduit for the processing of self- and intestinally absorbed antigens, leading to the induction of CD8+ T cells, that partake in the control of T cell activation during mucosal immune responses.

Original languageEnglish (US)
Pages (from-to)153-165
Number of pages13
JournalImmunity
Volume38
Issue number1
DOIs
StatePublished - Jan 24 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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