Circulatory changes in the reproductive tissues of ewes during pregnancy

Charles R. Rosenfeld, Frank H. Morriss, Edgar L. Makowski, Giacomo Meschia, Frederick C. Battaglia

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The blood flows to reproductive organs were measured by means of radionuclide–labeled microspheres in 24 pregnant ewes with gestational ages ranging from 38 to 141 days. The microsphcres were injected in the left ventricle of the non-anesthetized animal 4–7 days after surgery and while uterine blood flow was recorded continously by means of electromagnetic probes on both uterine arteries. The blood flow to ovaries with corpus luteum was maximum in early pregnancy and greater than in ovaries without corpus luteum. Placental blood flow increased from ~30 to ~300 ml/min during the stage of placental growth (40–90 days). In the last 50 days of pregnancy placental weight declined, whereas placental flow continued to rise and attained ~1,500 ml/min near term. The growth curves of fetal weight and placental blood flow followed a similar pattern, but the early increase in placental flow was more rapid than the increase in fetal weight. Hence placental flow per gram of fetus was larger in early pregnancy (~9 ml/min<sup>-g</sup>) than near term (~0.25 ml/min<sup>g</sup>). In twin pregnancies the placenta of each fetus received a smaller blood flow than the placenta of a singleton of comparable age. Mammary blood flow demonstrated no change until the last 60 days, when it increased from ~10 to ~200 ml/min. This phenomenon coincided with an increase in mammary weight and the final progressive increase of placental blood flow.

Original languageEnglish (US)
Pages (from-to)252-268
Number of pages17
JournalGynecologic and Obstetric Investigation
Volume5
Issue number5-6
DOIs
StatePublished - 1974

Fingerprint

Pregnancy
Fetal Weight
Corpus Luteum
Placenta
Ovary
Breast
Fetus
Weights and Measures
Uterine Artery
Twin Pregnancy
Electromagnetic Phenomena
Growth
Ambulatory Surgical Procedures
Microspheres
Gestational Age
Heart Ventricles

Keywords

  • Circulation
  • Fetus
  • Mammary blood flow
  • Ovaries
  • Placenta
  • Pregnancy
  • Radioactive microspheres
  • Uterine blood flow

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Circulatory changes in the reproductive tissues of ewes during pregnancy. / Rosenfeld, Charles R.; Morriss, Frank H.; Makowski, Edgar L.; Meschia, Giacomo; Battaglia, Frederick C.

In: Gynecologic and Obstetric Investigation, Vol. 5, No. 5-6, 1974, p. 252-268.

Research output: Contribution to journalArticle

Rosenfeld, Charles R. ; Morriss, Frank H. ; Makowski, Edgar L. ; Meschia, Giacomo ; Battaglia, Frederick C. / Circulatory changes in the reproductive tissues of ewes during pregnancy. In: Gynecologic and Obstetric Investigation. 1974 ; Vol. 5, No. 5-6. pp. 252-268.
@article{a5802a8ee0654abf91dc8f85b6e3065f,
title = "Circulatory changes in the reproductive tissues of ewes during pregnancy",
abstract = "The blood flows to reproductive organs were measured by means of radionuclide–labeled microspheres in 24 pregnant ewes with gestational ages ranging from 38 to 141 days. The microsphcres were injected in the left ventricle of the non-anesthetized animal 4–7 days after surgery and while uterine blood flow was recorded continously by means of electromagnetic probes on both uterine arteries. The blood flow to ovaries with corpus luteum was maximum in early pregnancy and greater than in ovaries without corpus luteum. Placental blood flow increased from ~30 to ~300 ml/min during the stage of placental growth (40–90 days). In the last 50 days of pregnancy placental weight declined, whereas placental flow continued to rise and attained ~1,500 ml/min near term. The growth curves of fetal weight and placental blood flow followed a similar pattern, but the early increase in placental flow was more rapid than the increase in fetal weight. Hence placental flow per gram of fetus was larger in early pregnancy (~9 ml/min-g) than near term (~0.25 ml/ming). In twin pregnancies the placenta of each fetus received a smaller blood flow than the placenta of a singleton of comparable age. Mammary blood flow demonstrated no change until the last 60 days, when it increased from ~10 to ~200 ml/min. This phenomenon coincided with an increase in mammary weight and the final progressive increase of placental blood flow.",
keywords = "Circulation, Fetus, Mammary blood flow, Ovaries, Placenta, Pregnancy, Radioactive microspheres, Uterine blood flow",
author = "Rosenfeld, {Charles R.} and Morriss, {Frank H.} and Makowski, {Edgar L.} and Giacomo Meschia and Battaglia, {Frederick C.}",
year = "1974",
doi = "10.1159/000301657",
language = "English (US)",
volume = "5",
pages = "252--268",
journal = "Gynecologic and Obstetric Investigation",
issn = "0378-7346",
publisher = "S. Karger AG",
number = "5-6",

}

TY - JOUR

T1 - Circulatory changes in the reproductive tissues of ewes during pregnancy

AU - Rosenfeld, Charles R.

AU - Morriss, Frank H.

AU - Makowski, Edgar L.

AU - Meschia, Giacomo

AU - Battaglia, Frederick C.

PY - 1974

Y1 - 1974

N2 - The blood flows to reproductive organs were measured by means of radionuclide–labeled microspheres in 24 pregnant ewes with gestational ages ranging from 38 to 141 days. The microsphcres were injected in the left ventricle of the non-anesthetized animal 4–7 days after surgery and while uterine blood flow was recorded continously by means of electromagnetic probes on both uterine arteries. The blood flow to ovaries with corpus luteum was maximum in early pregnancy and greater than in ovaries without corpus luteum. Placental blood flow increased from ~30 to ~300 ml/min during the stage of placental growth (40–90 days). In the last 50 days of pregnancy placental weight declined, whereas placental flow continued to rise and attained ~1,500 ml/min near term. The growth curves of fetal weight and placental blood flow followed a similar pattern, but the early increase in placental flow was more rapid than the increase in fetal weight. Hence placental flow per gram of fetus was larger in early pregnancy (~9 ml/min-g) than near term (~0.25 ml/ming). In twin pregnancies the placenta of each fetus received a smaller blood flow than the placenta of a singleton of comparable age. Mammary blood flow demonstrated no change until the last 60 days, when it increased from ~10 to ~200 ml/min. This phenomenon coincided with an increase in mammary weight and the final progressive increase of placental blood flow.

AB - The blood flows to reproductive organs were measured by means of radionuclide–labeled microspheres in 24 pregnant ewes with gestational ages ranging from 38 to 141 days. The microsphcres were injected in the left ventricle of the non-anesthetized animal 4–7 days after surgery and while uterine blood flow was recorded continously by means of electromagnetic probes on both uterine arteries. The blood flow to ovaries with corpus luteum was maximum in early pregnancy and greater than in ovaries without corpus luteum. Placental blood flow increased from ~30 to ~300 ml/min during the stage of placental growth (40–90 days). In the last 50 days of pregnancy placental weight declined, whereas placental flow continued to rise and attained ~1,500 ml/min near term. The growth curves of fetal weight and placental blood flow followed a similar pattern, but the early increase in placental flow was more rapid than the increase in fetal weight. Hence placental flow per gram of fetus was larger in early pregnancy (~9 ml/min-g) than near term (~0.25 ml/ming). In twin pregnancies the placenta of each fetus received a smaller blood flow than the placenta of a singleton of comparable age. Mammary blood flow demonstrated no change until the last 60 days, when it increased from ~10 to ~200 ml/min. This phenomenon coincided with an increase in mammary weight and the final progressive increase of placental blood flow.

KW - Circulation

KW - Fetus

KW - Mammary blood flow

KW - Ovaries

KW - Placenta

KW - Pregnancy

KW - Radioactive microspheres

KW - Uterine blood flow

UR - http://www.scopus.com/inward/record.url?scp=84940122871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940122871&partnerID=8YFLogxK

U2 - 10.1159/000301657

DO - 10.1159/000301657

M3 - Article

C2 - 4376754

AN - SCOPUS:84940122871

VL - 5

SP - 252

EP - 268

JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

SN - 0378-7346

IS - 5-6

ER -