Cisplatin-induced renal salt wasting syndrome

Tamim Hamdi, Shadi Latta, Bassel Jallad, Fayez Kheir, Mohamad N. Alhosaini, Ashok Patel

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Cisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal impairment with a decline in glomerular filtration has been the classical nephrotoxicity of cisplatin. Renal salt wasting syndrome is yet another, though it is not common. Previous studies were identified by searching the Pubmed database using the following keywords: cisplatin, cisplatin nephrotoxicity, renal salt wasting, and salt loosing nephropathy. Renal salt wasting syndrome has been described in 17 case reports since 1984. It is a rare side effect of cisplatin that manifests with polyuria, hypovolemia, and hyponatremia, and, because of similarities in clinical settings and laboratory values, it is frequently misdiagnosed as a syndrome of inappropriate antidiuretic hormone. Other causes of polyuria and hyponatremia should be excluded. Treatment aims at restoring the lost water and salt. Substituting cisplatin with carboplatin depends on individual clinical settings. Prognosis is excellent, as recovery was the rule in all the reported cases.

Original languageEnglish (US)
Pages (from-to)793-799
Number of pages7
JournalSouthern Medical Journal
Volume103
Issue number8
DOIs
StatePublished - Aug 2010

Fingerprint

Wasting Syndrome
Cisplatin
Salts
Kidney
Polyuria
Hyponatremia
Platinum Compounds
Hypovolemia
Carboplatin
Diagnostic Errors
Vasopressins
PubMed
Antineoplastic Agents
Databases
Water
Neoplasms

Keywords

  • cisplatin
  • renal salt wasting syndrome
  • salt and water replacement
  • sodium balance
  • syndrome of inappropriate antidiuretic hormone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hamdi, T., Latta, S., Jallad, B., Kheir, F., Alhosaini, M. N., & Patel, A. (2010). Cisplatin-induced renal salt wasting syndrome. Southern Medical Journal, 103(8), 793-799. https://doi.org/10.1097/SMJ.0b013e3181e63682

Cisplatin-induced renal salt wasting syndrome. / Hamdi, Tamim; Latta, Shadi; Jallad, Bassel; Kheir, Fayez; Alhosaini, Mohamad N.; Patel, Ashok.

In: Southern Medical Journal, Vol. 103, No. 8, 08.2010, p. 793-799.

Research output: Contribution to journalArticle

Hamdi, T, Latta, S, Jallad, B, Kheir, F, Alhosaini, MN & Patel, A 2010, 'Cisplatin-induced renal salt wasting syndrome', Southern Medical Journal, vol. 103, no. 8, pp. 793-799. https://doi.org/10.1097/SMJ.0b013e3181e63682
Hamdi T, Latta S, Jallad B, Kheir F, Alhosaini MN, Patel A. Cisplatin-induced renal salt wasting syndrome. Southern Medical Journal. 2010 Aug;103(8):793-799. https://doi.org/10.1097/SMJ.0b013e3181e63682
Hamdi, Tamim ; Latta, Shadi ; Jallad, Bassel ; Kheir, Fayez ; Alhosaini, Mohamad N. ; Patel, Ashok. / Cisplatin-induced renal salt wasting syndrome. In: Southern Medical Journal. 2010 ; Vol. 103, No. 8. pp. 793-799.
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