Citraturic response to oral citric acid load.

K. Sakhaee, R. Alpern, J. Poindexter, C. Y. Pak

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

It is possible that some orally administered citrate may appear in urine by escaping oxidation in vivo. To determine whether this mechanism contributes to the citraturic response to potassium citrate, we measured serum and urinary citrate for 4 hours after a single oral load of citric acid (40 mEq.) in 6 normal subjects. Since citric acid does not alter acid-base balance, the effect of absorbed citrate could be isolated from that of alkali load. Serum citrate concentration increased significantly (p less than 0.05) 30 minutes after a single oral dose of citric acid and remained significantly elevated for 3 hours after citric acid load. Commensurate with this change, urinary citrate excretion peaked at 2 hours and gradually decreased during the next 2 hours after citric acid load. In contrast, serum and urinary citrate remained unaltered following the control load (no drug). Differences of the citratemic and citraturic effects between phases were significant (p less than 0.05) at 2 and 3 hours. Urinary pH, carbon dioxide pressure, bicarbonate, total carbon dioxide and ammonium did not change at any time after citric acid load, and did not differ between the 2 phases. No significant difference was noted in serum electrolytes, arterialized venous pH and carbon dioxide pressure at any time after citric acid load and between the 2 phases. Thus, the citraturic and citratemic effects of oral citric acid are largely accountable by provision of absorbed citrate, which has escaped in vivo degradation.

Original languageEnglish (US)
Pages (from-to)975-976
Number of pages2
JournalJournal of Urology
Volume147
Issue number4
StatePublished - Apr 1992

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Citric Acid
Carbon Dioxide
Serum
Potassium Citrate
Pressure
Acid-Base Equilibrium
Alkalies
Bicarbonates
Ammonium Compounds
Electrolytes

ASJC Scopus subject areas

  • Urology

Cite this

Citraturic response to oral citric acid load. / Sakhaee, K.; Alpern, R.; Poindexter, J.; Pak, C. Y.

In: Journal of Urology, Vol. 147, No. 4, 04.1992, p. 975-976.

Research output: Contribution to journalArticle

Sakhaee, K, Alpern, R, Poindexter, J & Pak, CY 1992, 'Citraturic response to oral citric acid load.', Journal of Urology, vol. 147, no. 4, pp. 975-976.
Sakhaee, K. ; Alpern, R. ; Poindexter, J. ; Pak, C. Y. / Citraturic response to oral citric acid load. In: Journal of Urology. 1992 ; Vol. 147, No. 4. pp. 975-976.
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