Class II human leukocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis

Xiaojiang Gao, Edward J. Ball, Lori Dombrausky, Nancy J. Olsen, Theodore Pincus, Muhammad Asim Khan, Frederick Wolfe, Peter Stastny

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Human leukocyte antigen (HLA) typing was performed in 174 patients with rheumatoid arthritis and 222 white control subjects. Increases in HLA-DR4 and HLA-DR1 were observed as in previous studies. Each of these appeared to be inherited as dominant risk factors. Southern blotting with a DR-beta probe after digestion of genomic DNA with the restriction enzyme Bam HI showed seven bands. Three of them correlated with DR4 and were increased in rheumatoid arthritis patients. Subsets of DR4 were determined by polymerase chain reaction amplification followed by hybridization with oligonucleotide probes. Dw4 was increased in rheumatoid arthritis patients, and the frequency of the other subsets appeared to be similar in rheumatoid arthritis patients and control subjects. A polymorphism associated with the T cell receptor V-beta-8 gene family was significantly increased in rheumatoid arthritis patients.

Original languageEnglish (US)
Pages (from-to)14-16
Number of pages3
JournalThe American Journal of Medicine
Volume85
Issue number6 SUPPL. 1
DOIs
StatePublished - Dec 23 1988

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Class II human leukocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis'. Together they form a unique fingerprint.

  • Cite this

    Gao, X., Ball, E. J., Dombrausky, L., Olsen, N. J., Pincus, T., Khan, M. A., Wolfe, F., & Stastny, P. (1988). Class II human leukocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis. The American Journal of Medicine, 85(6 SUPPL. 1), 14-16. https://doi.org/10.1016/0002-9343(88)90373-7