Classification of cell death

Recommendations of the Nomenclature Committee on Cell Death 2009

G. Kroemer, L. Galluzzi, P. Vandenabeele, J. Abrams, E. S. Alnemri, E. H. Baehrecke, M. V. Blagosklonny, W. S. El-Deiry, P. Golstein, D. R. Green, M. Hengartner, R. A. Knight, S. Kumar, S. A. Lipton, W. Malorni, G. Nuñez, M. E. Peter, J. Tschopp, J. Yuan, M. Piacentini & 2 others B. Zhivotovsky, G. Melino

Research output: Contribution to journalArticle

1765 Citations (Scopus)

Abstract

Different types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death (NCCD) proposes unified criteria for the definition of cell death and of its different morphologies, while formulating several caveats against the misuse of words and concepts that slow down progress in the area of cell death research. Authors, reviewers and editors of scientific periodicals are invited to abandon expressions like 'percentage apoptosis' and to replace them with more accurate descriptions of the biochemical and cellular parameters that are actually measured. Moreover, at the present stage, it should be accepted that caspase-independent mechanisms can cooperate with (or substitute for) caspases in the execution of lethal signaling pathways and that 'autophagic cell death' is a type of cell death occurring together with (but not necessarily by) autophagic vacuolization. This study details the 2009 recommendations of the NCCD on the use of cell death-related terminology including 'entosis', 'mitotic catastrophe', 'necrosis', 'necroptosis' and 'pyroptosis'.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalCell Death and Differentiation
Volume16
Issue number1
DOIs
StatePublished - 2009

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Terminology
Cell Death
Caspases
Entosis
Autophagy
Necrosis
Apoptosis
Research

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., ... Melino, G. (2009). Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death and Differentiation, 16(1), 3-11. https://doi.org/10.1038/cdd.2008.150

Classification of cell death : Recommendations of the Nomenclature Committee on Cell Death 2009. / Kroemer, G.; Galluzzi, L.; Vandenabeele, P.; Abrams, J.; Alnemri, E. S.; Baehrecke, E. H.; Blagosklonny, M. V.; El-Deiry, W. S.; Golstein, P.; Green, D. R.; Hengartner, M.; Knight, R. A.; Kumar, S.; Lipton, S. A.; Malorni, W.; Nuñez, G.; Peter, M. E.; Tschopp, J.; Yuan, J.; Piacentini, M.; Zhivotovsky, B.; Melino, G.

In: Cell Death and Differentiation, Vol. 16, No. 1, 2009, p. 3-11.

Research output: Contribution to journalArticle

Kroemer, G, Galluzzi, L, Vandenabeele, P, Abrams, J, Alnemri, ES, Baehrecke, EH, Blagosklonny, MV, El-Deiry, WS, Golstein, P, Green, DR, Hengartner, M, Knight, RA, Kumar, S, Lipton, SA, Malorni, W, Nuñez, G, Peter, ME, Tschopp, J, Yuan, J, Piacentini, M, Zhivotovsky, B & Melino, G 2009, 'Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009', Cell Death and Differentiation, vol. 16, no. 1, pp. 3-11. https://doi.org/10.1038/cdd.2008.150
Kroemer, G. ; Galluzzi, L. ; Vandenabeele, P. ; Abrams, J. ; Alnemri, E. S. ; Baehrecke, E. H. ; Blagosklonny, M. V. ; El-Deiry, W. S. ; Golstein, P. ; Green, D. R. ; Hengartner, M. ; Knight, R. A. ; Kumar, S. ; Lipton, S. A. ; Malorni, W. ; Nuñez, G. ; Peter, M. E. ; Tschopp, J. ; Yuan, J. ; Piacentini, M. ; Zhivotovsky, B. ; Melino, G. / Classification of cell death : Recommendations of the Nomenclature Committee on Cell Death 2009. In: Cell Death and Differentiation. 2009 ; Vol. 16, No. 1. pp. 3-11.
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