Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography

Chih Hao Liu, Yong Du, Manmohan Singh, Chen Wu, Zhaolong Han, Jiasong Li, Anthony Chang, Chandra Mohan, Kirill V. Larin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Acute glomerulonephritis caused by antiglomerular basement membrane marked by high mortality. The primary reason for this is delayed diagnosis via blood examination, urine analysis, tissue biopsy, or ultrasound and X-ray computed tomography imaging. Blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution, with reduced sensitivity. Optical coherence tomography is a noninvasive and high-resolution imaging technique that provides superior spatial resolution (micrometer scale) as compared to ultrasound and CT. Changes in tissue properties can be detected based on the optical metrics analyzed from the OCT signals, such as optical attenuation and speckle variance. Furthermore, OCT does not rely on ionizing radiation as with CT imaging. In addition to structural changes, the elasticity of the kidney can significantly change due to nephritis. In this work, OCT has been utilized to quantify the difference in tissue properties between healthy and nephritic murine kidneys. Although OCT imaging could identify the diseased tissue, its classification accuracy is clinically inadequate. By combining optical metrics with elasticity, the classification accuracy improves from 76% to 95%. These results show that OCT combined with OCE can be a powerful tool for identifying and classifying nephritis. Therefore, the OCT/OCE method could potentially be used as a minimally invasive tool for longitudinal studies during the progression and therapy of glomerulonephritis as well as complement and, perhaps, substitute highly invasive tissue biopsies. (Figure presented.) Elastic-wave propagation in mouse healthy and nephritic kidneys.

Original languageEnglish (US)
Pages (from-to)781-791
Number of pages11
JournalJournal of Biophotonics
Volume9
Issue number8
DOIs
StatePublished - Aug 1 2016

Fingerprint

Elasticity Imaging Techniques
Optical tomography
Optical Coherence Tomography
Glomerulonephritis
classifying
tomography
Tissue
nephritis
Kidney
Imaging techniques
kidneys
urine
Nephritis
Biopsy
Ultrasonics
Elasticity
blood
Blood
elastic properties
spatial resolution

Keywords

  • elastic-wave velocity
  • elasticity optical coherence elastography
  • glomerulonephritis
  • optical attenuation
  • speckle variance
  • Young's modulus

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography. / Liu, Chih Hao; Du, Yong; Singh, Manmohan; Wu, Chen; Han, Zhaolong; Li, Jiasong; Chang, Anthony; Mohan, Chandra; Larin, Kirill V.

In: Journal of Biophotonics, Vol. 9, No. 8, 01.08.2016, p. 781-791.

Research output: Contribution to journalArticle

Liu, CH, Du, Y, Singh, M, Wu, C, Han, Z, Li, J, Chang, A, Mohan, C & Larin, KV 2016, 'Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography', Journal of Biophotonics, vol. 9, no. 8, pp. 781-791. https://doi.org/10.1002/jbio.201500269
Liu, Chih Hao ; Du, Yong ; Singh, Manmohan ; Wu, Chen ; Han, Zhaolong ; Li, Jiasong ; Chang, Anthony ; Mohan, Chandra ; Larin, Kirill V. / Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography. In: Journal of Biophotonics. 2016 ; Vol. 9, No. 8. pp. 781-791.
@article{06833ee5f5af4596b1c5e406e3fe7cb5,
title = "Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography",
abstract = "Acute glomerulonephritis caused by antiglomerular basement membrane marked by high mortality. The primary reason for this is delayed diagnosis via blood examination, urine analysis, tissue biopsy, or ultrasound and X-ray computed tomography imaging. Blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution, with reduced sensitivity. Optical coherence tomography is a noninvasive and high-resolution imaging technique that provides superior spatial resolution (micrometer scale) as compared to ultrasound and CT. Changes in tissue properties can be detected based on the optical metrics analyzed from the OCT signals, such as optical attenuation and speckle variance. Furthermore, OCT does not rely on ionizing radiation as with CT imaging. In addition to structural changes, the elasticity of the kidney can significantly change due to nephritis. In this work, OCT has been utilized to quantify the difference in tissue properties between healthy and nephritic murine kidneys. Although OCT imaging could identify the diseased tissue, its classification accuracy is clinically inadequate. By combining optical metrics with elasticity, the classification accuracy improves from 76{\%} to 95{\%}. These results show that OCT combined with OCE can be a powerful tool for identifying and classifying nephritis. Therefore, the OCT/OCE method could potentially be used as a minimally invasive tool for longitudinal studies during the progression and therapy of glomerulonephritis as well as complement and, perhaps, substitute highly invasive tissue biopsies. (Figure presented.) Elastic-wave propagation in mouse healthy and nephritic kidneys.",
keywords = "elastic-wave velocity, elasticity optical coherence elastography, glomerulonephritis, optical attenuation, speckle variance, Young's modulus",
author = "Liu, {Chih Hao} and Yong Du and Manmohan Singh and Chen Wu and Zhaolong Han and Jiasong Li and Anthony Chang and Chandra Mohan and Larin, {Kirill V.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1002/jbio.201500269",
language = "English (US)",
volume = "9",
pages = "781--791",
journal = "Journal of Biophotonics",
issn = "1864-063X",
publisher = "Wiley-VCH Verlag",
number = "8",

}

TY - JOUR

T1 - Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography

AU - Liu, Chih Hao

AU - Du, Yong

AU - Singh, Manmohan

AU - Wu, Chen

AU - Han, Zhaolong

AU - Li, Jiasong

AU - Chang, Anthony

AU - Mohan, Chandra

AU - Larin, Kirill V.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Acute glomerulonephritis caused by antiglomerular basement membrane marked by high mortality. The primary reason for this is delayed diagnosis via blood examination, urine analysis, tissue biopsy, or ultrasound and X-ray computed tomography imaging. Blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution, with reduced sensitivity. Optical coherence tomography is a noninvasive and high-resolution imaging technique that provides superior spatial resolution (micrometer scale) as compared to ultrasound and CT. Changes in tissue properties can be detected based on the optical metrics analyzed from the OCT signals, such as optical attenuation and speckle variance. Furthermore, OCT does not rely on ionizing radiation as with CT imaging. In addition to structural changes, the elasticity of the kidney can significantly change due to nephritis. In this work, OCT has been utilized to quantify the difference in tissue properties between healthy and nephritic murine kidneys. Although OCT imaging could identify the diseased tissue, its classification accuracy is clinically inadequate. By combining optical metrics with elasticity, the classification accuracy improves from 76% to 95%. These results show that OCT combined with OCE can be a powerful tool for identifying and classifying nephritis. Therefore, the OCT/OCE method could potentially be used as a minimally invasive tool for longitudinal studies during the progression and therapy of glomerulonephritis as well as complement and, perhaps, substitute highly invasive tissue biopsies. (Figure presented.) Elastic-wave propagation in mouse healthy and nephritic kidneys.

AB - Acute glomerulonephritis caused by antiglomerular basement membrane marked by high mortality. The primary reason for this is delayed diagnosis via blood examination, urine analysis, tissue biopsy, or ultrasound and X-ray computed tomography imaging. Blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution, with reduced sensitivity. Optical coherence tomography is a noninvasive and high-resolution imaging technique that provides superior spatial resolution (micrometer scale) as compared to ultrasound and CT. Changes in tissue properties can be detected based on the optical metrics analyzed from the OCT signals, such as optical attenuation and speckle variance. Furthermore, OCT does not rely on ionizing radiation as with CT imaging. In addition to structural changes, the elasticity of the kidney can significantly change due to nephritis. In this work, OCT has been utilized to quantify the difference in tissue properties between healthy and nephritic murine kidneys. Although OCT imaging could identify the diseased tissue, its classification accuracy is clinically inadequate. By combining optical metrics with elasticity, the classification accuracy improves from 76% to 95%. These results show that OCT combined with OCE can be a powerful tool for identifying and classifying nephritis. Therefore, the OCT/OCE method could potentially be used as a minimally invasive tool for longitudinal studies during the progression and therapy of glomerulonephritis as well as complement and, perhaps, substitute highly invasive tissue biopsies. (Figure presented.) Elastic-wave propagation in mouse healthy and nephritic kidneys.

KW - elastic-wave velocity

KW - elasticity optical coherence elastography

KW - glomerulonephritis

KW - optical attenuation

KW - speckle variance

KW - Young's modulus

UR - http://www.scopus.com/inward/record.url?scp=85027940462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027940462&partnerID=8YFLogxK

U2 - 10.1002/jbio.201500269

DO - 10.1002/jbio.201500269

M3 - Article

C2 - 26791097

AN - SCOPUS:85027940462

VL - 9

SP - 781

EP - 791

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 8

ER -