Clearance of ticarcillin-clavulanic acid by continuous venovenous hemofiltration in three critically ill children, two with and one without concomitant extracorporeal membrane oxygenation

Christine A. Lindsay, Roger Bawdon, Raymond Quigley

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Three children were receiving ticarcillin-clavulanic acid by continuous venovenous hemofiltration (CVVH). Two of them were also receiving concomitant extracorporeal membrane oxygenation (ECMO). We collected ultrafiltrate hourly to determine the clearance of ticarcillin-clavulanic acid by CVVH. Serum concentrations were also determined at the midpoint of each ultrafiltrate collection. All samples were collected over one dosing interval. The volume of distribution of ticarcillin and clavulanic acid was 0.26. ± 0.01 and 0.69 ± 0.23 L/kg, respectively. Total body clearance of ticarcillin, determined from the elimination rate constant and volume of distribution, was 0.038 ± 0.003 L/kg/hour and for clavulanic acid was 0.18 ± 0.03 L/kg/hour. The sieving coefficients for ticarcillin and clavulanic acid were 0.83 ± 0.11 and 1.69 ± 0.19, respectively. We attempted to estimate the clearances by ECMO, but the result was uninterpretable.

Original languageEnglish (US)
Pages (from-to)458-462
Number of pages5
JournalPharmacotherapy
Volume16
Issue number3 I
StatePublished - 1996

Fingerprint

Hemofiltration
Extracorporeal Membrane Oxygenation
Critical Illness
Ticarcillin
Clavulanic Acid
ticarcillin-clavulanic acid
Serum

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{f8e2d8b589824294b7f23ac14a2c514d,
title = "Clearance of ticarcillin-clavulanic acid by continuous venovenous hemofiltration in three critically ill children, two with and one without concomitant extracorporeal membrane oxygenation",
abstract = "Three children were receiving ticarcillin-clavulanic acid by continuous venovenous hemofiltration (CVVH). Two of them were also receiving concomitant extracorporeal membrane oxygenation (ECMO). We collected ultrafiltrate hourly to determine the clearance of ticarcillin-clavulanic acid by CVVH. Serum concentrations were also determined at the midpoint of each ultrafiltrate collection. All samples were collected over one dosing interval. The volume of distribution of ticarcillin and clavulanic acid was 0.26. ± 0.01 and 0.69 ± 0.23 L/kg, respectively. Total body clearance of ticarcillin, determined from the elimination rate constant and volume of distribution, was 0.038 ± 0.003 L/kg/hour and for clavulanic acid was 0.18 ± 0.03 L/kg/hour. The sieving coefficients for ticarcillin and clavulanic acid were 0.83 ± 0.11 and 1.69 ± 0.19, respectively. We attempted to estimate the clearances by ECMO, but the result was uninterpretable.",
author = "Lindsay, {Christine A.} and Roger Bawdon and Raymond Quigley",
year = "1996",
language = "English (US)",
volume = "16",
pages = "458--462",
journal = "Pharmacotherapy",
issn = "0277-0008",
publisher = "Pharmacotherapy Publications Inc.",
number = "3 I",

}

TY - JOUR

T1 - Clearance of ticarcillin-clavulanic acid by continuous venovenous hemofiltration in three critically ill children, two with and one without concomitant extracorporeal membrane oxygenation

AU - Lindsay, Christine A.

AU - Bawdon, Roger

AU - Quigley, Raymond

PY - 1996

Y1 - 1996

N2 - Three children were receiving ticarcillin-clavulanic acid by continuous venovenous hemofiltration (CVVH). Two of them were also receiving concomitant extracorporeal membrane oxygenation (ECMO). We collected ultrafiltrate hourly to determine the clearance of ticarcillin-clavulanic acid by CVVH. Serum concentrations were also determined at the midpoint of each ultrafiltrate collection. All samples were collected over one dosing interval. The volume of distribution of ticarcillin and clavulanic acid was 0.26. ± 0.01 and 0.69 ± 0.23 L/kg, respectively. Total body clearance of ticarcillin, determined from the elimination rate constant and volume of distribution, was 0.038 ± 0.003 L/kg/hour and for clavulanic acid was 0.18 ± 0.03 L/kg/hour. The sieving coefficients for ticarcillin and clavulanic acid were 0.83 ± 0.11 and 1.69 ± 0.19, respectively. We attempted to estimate the clearances by ECMO, but the result was uninterpretable.

AB - Three children were receiving ticarcillin-clavulanic acid by continuous venovenous hemofiltration (CVVH). Two of them were also receiving concomitant extracorporeal membrane oxygenation (ECMO). We collected ultrafiltrate hourly to determine the clearance of ticarcillin-clavulanic acid by CVVH. Serum concentrations were also determined at the midpoint of each ultrafiltrate collection. All samples were collected over one dosing interval. The volume of distribution of ticarcillin and clavulanic acid was 0.26. ± 0.01 and 0.69 ± 0.23 L/kg, respectively. Total body clearance of ticarcillin, determined from the elimination rate constant and volume of distribution, was 0.038 ± 0.003 L/kg/hour and for clavulanic acid was 0.18 ± 0.03 L/kg/hour. The sieving coefficients for ticarcillin and clavulanic acid were 0.83 ± 0.11 and 1.69 ± 0.19, respectively. We attempted to estimate the clearances by ECMO, but the result was uninterpretable.

UR - http://www.scopus.com/inward/record.url?scp=0030013340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030013340&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 458

EP - 462

JO - Pharmacotherapy

JF - Pharmacotherapy

SN - 0277-0008

IS - 3 I

ER -