Clinical and demographic features of atypical depression in outpatients with major depressive disorder

Preliminary findings from STAR*D

Jon S. Novick, Jonathan W. Stewart, Stephen R. Wisniewski, Ian A. Cook, Radmila Manev, Andrew A. Nierenberg, Jerrold F. Rosenbaum, Kathy Shores-Wilson, G. K. Balasubramani, Melanie M. Biggs, Sid Zisook, A. John Rush

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Objective: To determine the frequency and demographic and clinical characteristics of depression with atypical features in a broadly representative sample of outpatients. Method: Data derived from the first 1500 patients with DSM-IV major depressive disorder enrolled in the Sequenced Treatment Alternatives to Relieve Depression trial at 41 primary care and nonresearch psychiatric outpatient clinics. An algorithm based on the 30-item Inventory of Depressive Symptomatology-Clinician Rating (IDS-C30) determined presence or absence of depression with atypical features. Odds ratios determined whether a variety of demographic and clinical parameters differed between patients meeting and not meeting atypical criteria. Results: Over 18% of the sample met criteria for atypical features based on items from the IDS-C30. The atypical group was more likely to be female and have an earlier age at onset, greater comorbidity with anxiety symptoms, and greater symptom severity compared with the nonatypical group. Conclusion: Previously identified features of atypical depression were confirmed in this large and broadly representative, nonresearch clinical population.

Original languageEnglish (US)
Pages (from-to)1002-1011
Number of pages10
JournalJournal of Clinical Psychiatry
Volume66
Issue number8
StatePublished - Aug 2005

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Major Depressive Disorder
Outpatients
Demography
Depression
Ambulatory Care Facilities
Age of Onset
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Comorbidity
Primary Health Care
Anxiety
Odds Ratio
Equipment and Supplies
Population
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Novick, J. S., Stewart, J. W., Wisniewski, S. R., Cook, I. A., Manev, R., Nierenberg, A. A., ... Rush, A. J. (2005). Clinical and demographic features of atypical depression in outpatients with major depressive disorder: Preliminary findings from STAR*D. Journal of Clinical Psychiatry, 66(8), 1002-1011.

Clinical and demographic features of atypical depression in outpatients with major depressive disorder : Preliminary findings from STAR*D. / Novick, Jon S.; Stewart, Jonathan W.; Wisniewski, Stephen R.; Cook, Ian A.; Manev, Radmila; Nierenberg, Andrew A.; Rosenbaum, Jerrold F.; Shores-Wilson, Kathy; Balasubramani, G. K.; Biggs, Melanie M.; Zisook, Sid; Rush, A. John.

In: Journal of Clinical Psychiatry, Vol. 66, No. 8, 08.2005, p. 1002-1011.

Research output: Contribution to journalArticle

Novick, JS, Stewart, JW, Wisniewski, SR, Cook, IA, Manev, R, Nierenberg, AA, Rosenbaum, JF, Shores-Wilson, K, Balasubramani, GK, Biggs, MM, Zisook, S & Rush, AJ 2005, 'Clinical and demographic features of atypical depression in outpatients with major depressive disorder: Preliminary findings from STAR*D', Journal of Clinical Psychiatry, vol. 66, no. 8, pp. 1002-1011.
Novick, Jon S. ; Stewart, Jonathan W. ; Wisniewski, Stephen R. ; Cook, Ian A. ; Manev, Radmila ; Nierenberg, Andrew A. ; Rosenbaum, Jerrold F. ; Shores-Wilson, Kathy ; Balasubramani, G. K. ; Biggs, Melanie M. ; Zisook, Sid ; Rush, A. John. / Clinical and demographic features of atypical depression in outpatients with major depressive disorder : Preliminary findings from STAR*D. In: Journal of Clinical Psychiatry. 2005 ; Vol. 66, No. 8. pp. 1002-1011.
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