Clinical and Infection Prevention Applications of Severe Acute Respiratory Syndrome Coronavirus 2 Genotyping: An Infectious Diseases Society of America/American Society for Microbiology Consensus Review Document

Alexander L. Greninger, Jennifer Dien Bard, Robert C. Colgrove, Erin H. Graf, Kimberly E. Hanson, Mary K. Hayden, Romney M. Humphries, Christopher F. Lowe, Melissa B. Miller, Dylan R. Pillai, Daniel D. Rhoads, Joseph D. Yao, Francesca M. Lee

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged into a world of maturing pathogen genomics, with >2 million genomes sequenced at this writing. The rise of more transmissible variants of concern that affect vaccine and therapeutic effectiveness has led to widespread interest in SARS-CoV-2 evolution. Clinicians are also eager to take advantage of the information provided by SARS-CoV-2 genotyping beyond surveillance purposes. Here, we review the potential role of SARS-CoV-2 genotyping in clinical care. The review covers clinical use cases for SARS-CoV-2 genotyping, methods of SARS-CoV-2 genotyping, assay validation and regulatory requirements, clinical reporting for laboratories, and emerging issues in clinical SARS-CoV-2 sequencing. While clinical uses of SARS-CoV-2 genotyping are currently limited, rapid technological change along with a growing ability to interpret variants in real time foretell a growing role for SARS-CoV-2 genotyping in clinical care as continuing data emerge on vaccine and therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)1496-1502
Number of pages7
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume74
Issue number8
DOIs
StatePublished - Apr 28 2022

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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