Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum

Chellamani Harini, Rohit R. Das, Sanjay P. Prabhu, Kanwaljit Singh, Amit Haldar, Masanori Takeoka, Ann M. Bergin, Tobias Loddenkemper, Sanjeev V. Kothare

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

PURPOSE: T2-hyperintense signal changes in corpus callosum (CC) have been described in epilepsy and encephalitis/encephalopathy. Little is known about their pathophysiology. The aim of this study was to examine the clinical presentation and evolution of CC lesions and relationship to seizures. METHODS: We identified 12 children among 29,634 patients from Radiology Database. We evaluated following characteristics: seizures and accompanying medical history, antiepileptic drug usage, presenting symptoms, and radiological evolution of lesions. RESULTS: CC lesions were seen in patients with prior diagnosis of epilepsy (n = 5) or in those with new onset seizures (n = 3), or with encephalitis/encephalopathy without history of seizures (n = 4). Seizure clustering or disturbances of consciousness were the main presenting symptoms. No relationship was observed between CC lesion and AEDs. On imaging, ovoid lesions at presentation resolved on follow up imaging and linear lesions persisted. DTI showed that the fibers passing through splenial lesions originated from the posterior parietal cortex and occipital cortex bilaterally. CONCLUSION: In patients with seizures, no clear relationship was demonstrated between seizure characteristics or AED use with CC lesions. Ovoid lesions resolved and may have different pathophysiologic mechanism when compared to linear lesions that persisted.

Original languageEnglish (US)
Pages (from-to)824-831
Number of pages8
JournalJournal of Neuroimaging
Volume25
Issue number5
DOIs
StatePublished - Jan 1 2015

Fingerprint

Corpus Callosum
Neuroimaging
Seizures
Brain Diseases
Encephalitis
Epilepsy
Occipital Lobe
Parietal Lobe
Consciousness
Radiology
Anticonvulsants
Cluster Analysis
Databases

Keywords

  • Antiepileptic drugs
  • Corpus callosum
  • Encephalitis
  • Encephalopathy
  • MRI
  • Splenial lesions

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Harini, C., Das, R. R., Prabhu, S. P., Singh, K., Haldar, A., Takeoka, M., ... Kothare, S. V. (2015). Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. Journal of Neuroimaging, 25(5), 824-831. https://doi.org/10.1111/jon.12190

Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. / Harini, Chellamani; Das, Rohit R.; Prabhu, Sanjay P.; Singh, Kanwaljit; Haldar, Amit; Takeoka, Masanori; Bergin, Ann M.; Loddenkemper, Tobias; Kothare, Sanjeev V.

In: Journal of Neuroimaging, Vol. 25, No. 5, 01.01.2015, p. 824-831.

Research output: Contribution to journalArticle

Harini, C, Das, RR, Prabhu, SP, Singh, K, Haldar, A, Takeoka, M, Bergin, AM, Loddenkemper, T & Kothare, SV 2015, 'Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum', Journal of Neuroimaging, vol. 25, no. 5, pp. 824-831. https://doi.org/10.1111/jon.12190
Harini, Chellamani ; Das, Rohit R. ; Prabhu, Sanjay P. ; Singh, Kanwaljit ; Haldar, Amit ; Takeoka, Masanori ; Bergin, Ann M. ; Loddenkemper, Tobias ; Kothare, Sanjeev V. / Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum. In: Journal of Neuroimaging. 2015 ; Vol. 25, No. 5. pp. 824-831.
@article{7e2a65f8d65a410aa379bb6c133bb853,
title = "Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum",
abstract = "PURPOSE: T2-hyperintense signal changes in corpus callosum (CC) have been described in epilepsy and encephalitis/encephalopathy. Little is known about their pathophysiology. The aim of this study was to examine the clinical presentation and evolution of CC lesions and relationship to seizures. METHODS: We identified 12 children among 29,634 patients from Radiology Database. We evaluated following characteristics: seizures and accompanying medical history, antiepileptic drug usage, presenting symptoms, and radiological evolution of lesions. RESULTS: CC lesions were seen in patients with prior diagnosis of epilepsy (n = 5) or in those with new onset seizures (n = 3), or with encephalitis/encephalopathy without history of seizures (n = 4). Seizure clustering or disturbances of consciousness were the main presenting symptoms. No relationship was observed between CC lesion and AEDs. On imaging, ovoid lesions at presentation resolved on follow up imaging and linear lesions persisted. DTI showed that the fibers passing through splenial lesions originated from the posterior parietal cortex and occipital cortex bilaterally. CONCLUSION: In patients with seizures, no clear relationship was demonstrated between seizure characteristics or AED use with CC lesions. Ovoid lesions resolved and may have different pathophysiologic mechanism when compared to linear lesions that persisted.",
keywords = "Antiepileptic drugs, Corpus callosum, Encephalitis, Encephalopathy, MRI, Splenial lesions",
author = "Chellamani Harini and Das, {Rohit R.} and Prabhu, {Sanjay P.} and Kanwaljit Singh and Amit Haldar and Masanori Takeoka and Bergin, {Ann M.} and Tobias Loddenkemper and Kothare, {Sanjeev V.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1111/jon.12190",
language = "English (US)",
volume = "25",
pages = "824--831",
journal = "Journal of Neuroimaging",
issn = "1051-2284",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Clinical and Neuroimaging Profile of Children with Lesions in the Corpus Callosum

AU - Harini, Chellamani

AU - Das, Rohit R.

AU - Prabhu, Sanjay P.

AU - Singh, Kanwaljit

AU - Haldar, Amit

AU - Takeoka, Masanori

AU - Bergin, Ann M.

AU - Loddenkemper, Tobias

AU - Kothare, Sanjeev V.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - PURPOSE: T2-hyperintense signal changes in corpus callosum (CC) have been described in epilepsy and encephalitis/encephalopathy. Little is known about their pathophysiology. The aim of this study was to examine the clinical presentation and evolution of CC lesions and relationship to seizures. METHODS: We identified 12 children among 29,634 patients from Radiology Database. We evaluated following characteristics: seizures and accompanying medical history, antiepileptic drug usage, presenting symptoms, and radiological evolution of lesions. RESULTS: CC lesions were seen in patients with prior diagnosis of epilepsy (n = 5) or in those with new onset seizures (n = 3), or with encephalitis/encephalopathy without history of seizures (n = 4). Seizure clustering or disturbances of consciousness were the main presenting symptoms. No relationship was observed between CC lesion and AEDs. On imaging, ovoid lesions at presentation resolved on follow up imaging and linear lesions persisted. DTI showed that the fibers passing through splenial lesions originated from the posterior parietal cortex and occipital cortex bilaterally. CONCLUSION: In patients with seizures, no clear relationship was demonstrated between seizure characteristics or AED use with CC lesions. Ovoid lesions resolved and may have different pathophysiologic mechanism when compared to linear lesions that persisted.

AB - PURPOSE: T2-hyperintense signal changes in corpus callosum (CC) have been described in epilepsy and encephalitis/encephalopathy. Little is known about their pathophysiology. The aim of this study was to examine the clinical presentation and evolution of CC lesions and relationship to seizures. METHODS: We identified 12 children among 29,634 patients from Radiology Database. We evaluated following characteristics: seizures and accompanying medical history, antiepileptic drug usage, presenting symptoms, and radiological evolution of lesions. RESULTS: CC lesions were seen in patients with prior diagnosis of epilepsy (n = 5) or in those with new onset seizures (n = 3), or with encephalitis/encephalopathy without history of seizures (n = 4). Seizure clustering or disturbances of consciousness were the main presenting symptoms. No relationship was observed between CC lesion and AEDs. On imaging, ovoid lesions at presentation resolved on follow up imaging and linear lesions persisted. DTI showed that the fibers passing through splenial lesions originated from the posterior parietal cortex and occipital cortex bilaterally. CONCLUSION: In patients with seizures, no clear relationship was demonstrated between seizure characteristics or AED use with CC lesions. Ovoid lesions resolved and may have different pathophysiologic mechanism when compared to linear lesions that persisted.

KW - Antiepileptic drugs

KW - Corpus callosum

KW - Encephalitis

KW - Encephalopathy

KW - MRI

KW - Splenial lesions

UR - http://www.scopus.com/inward/record.url?scp=84939255777&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939255777&partnerID=8YFLogxK

U2 - 10.1111/jon.12190

DO - 10.1111/jon.12190

M3 - Article

VL - 25

SP - 824

EP - 831

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

SN - 1051-2284

IS - 5

ER -