Clinical and ocular histopathological findings in a patient with normal- pressure glaucoma

Martin B. Wax, Gülgün Tezel, P. Deepak Edward

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Objective: To study the histopathological changes of eyes from a patient with normal-pressure glaucoma whose clinical and laboratory findings were well documented. Methods: Postmortem histopathological findings in a patient with normal-pressure glaucoma who had monoclonal gammopathy and serum immunoreactivity to retinal proteins were examined in comparison with those of an age-matched control subject. Clinicopathological correlations to laboratory findings were examined. Results: Clinical and histopathological findings of the patient, including cavernous degeneration of optic nerve and characteristic optic nerve cupping, were similar to those in patients with glaucoma who had high intraocular pressure. In addition, we found immunoglobulin G and immunoglobulin A deposition in the ganglion cells, inner and outer nuclear layers of the retina, and evidence of apoptotic retinal cell death using terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling technique. Conclusions: Serum antibodies to retinal proteins and retinal immunoglobulin deposition constitute novel findings in a patient with normal-pressure glaucoma and may contribute to better understanding of the mechanisms underlying glaucomatous optic neuropathy in this disorder.

Original languageEnglish (US)
Pages (from-to)993-1001
Number of pages9
JournalArchives of Ophthalmology
Volume116
Issue number8
StatePublished - Aug 1998

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Glaucoma
Pressure
Optic Nerve
Optic Nerve Diseases
Paraproteinemias
DNA Nucleotidylexotransferase
Serum
Intraocular Pressure
Ganglia
Immunoglobulin A
Retina
Immunoglobulins
Proteins
Cell Death
Immunoglobulin G
Antibodies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Clinical and ocular histopathological findings in a patient with normal- pressure glaucoma. / Wax, Martin B.; Tezel, Gülgün; Edward, P. Deepak.

In: Archives of Ophthalmology, Vol. 116, No. 8, 08.1998, p. 993-1001.

Research output: Contribution to journalArticle

Wax, Martin B. ; Tezel, Gülgün ; Edward, P. Deepak. / Clinical and ocular histopathological findings in a patient with normal- pressure glaucoma. In: Archives of Ophthalmology. 1998 ; Vol. 116, No. 8. pp. 993-1001.
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