Clinical and radiologic manifestations of hypersensitivity pneumonitis

Craig S. Glazer, Cecile S. Rose, David A. Lynch

Research output: Contribution to journalReview article

76 Scopus citations

Abstract

Hypersensitivity pneumonitis (HP) is an inflammatory interstitial lung disease caused by recurring exposure to a variety of occupational and environmental antigens. It features widely variable clinical, radiologic, and histopathologic findings. Because the clinical findings of HP mimic multiple other diseases, a high degree of clinical suspicion and a thorough occupational and environmental history are essential for accurate diagnosis. There is no single pathognomonic feature for HP, rather, diagnosis relies on a constellation of clinical, radiologic, and pathologic findings. The radiologic manifestations, particularly the high-resolution computed tomography (HRCT) pattern, provide important clues and frequently point clinicians towards the correct diagnosis. The HRCT findings in HP may include ground-glass opacification, centrilobular nodules, air trapping (mosaic pattern), fibrosis, emphysema, or more frequently a combination of these. The combination of a mosaic pattern with ground-glass opacification and centrilobular nodules is particularly suggestive of the diagnosis. The best long-term prognosis is achieved with early diagnosis and removal from exposure.

Original languageEnglish (US)
Pages (from-to)261-272
Number of pages12
JournalJournal of thoracic imaging
Volume17
Issue number4
DOIs
StatePublished - Oct 1 2002

Keywords

  • Bioaerosols
  • Extrinsic allergic alveolitis
  • Granuloma
  • Hypersensitivity pneumonitis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pulmonary and Respiratory Medicine

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