Abstract
Hypersensitivity pneumonitis (HP) is an inflammatory interstitial lung disease caused by recurring exposure to a variety of occupational and environmental antigens. It features widely variable clinical, radiologic, and histopathologic findings. Because the clinical findings of HP mimic multiple other diseases, a high degree of clinical suspicion and a thorough occupational and environmental history are essential for accurate diagnosis. There is no single pathognomonic feature for HP, rather, diagnosis relies on a constellation of clinical, radiologic, and pathologic findings. The radiologic manifestations, particularly the high-resolution computed tomography (HRCT) pattern, provide important clues and frequently point clinicians towards the correct diagnosis. The HRCT findings in HP may include ground-glass opacification, centrilobular nodules, air trapping (mosaic pattern), fibrosis, emphysema, or more frequently a combination of these. The combination of a mosaic pattern with ground-glass opacification and centrilobular nodules is particularly suggestive of the diagnosis. The best long-term prognosis is achieved with early diagnosis and removal from exposure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 261-272 |
| Number of pages | 12 |
| Journal | Journal of Thoracic Imaging |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2002 |
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Keywords
- Bioaerosols
- Extrinsic allergic alveolitis
- Granuloma
- Hypersensitivity pneumonitis
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Pulmonary and Respiratory Medicine
- Radiological and Ultrasound Technology
Cite this
Clinical and radiologic manifestations of hypersensitivity pneumonitis. / Glazer, Craig S.; Rose, Cecile S.; Lynch, David A.
In: Journal of Thoracic Imaging, Vol. 17, No. 4, 10.2002, p. 261-272.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical and radiologic manifestations of hypersensitivity pneumonitis
AU - Glazer, Craig S.
AU - Rose, Cecile S.
AU - Lynch, David A.
PY - 2002/10
Y1 - 2002/10
N2 - Hypersensitivity pneumonitis (HP) is an inflammatory interstitial lung disease caused by recurring exposure to a variety of occupational and environmental antigens. It features widely variable clinical, radiologic, and histopathologic findings. Because the clinical findings of HP mimic multiple other diseases, a high degree of clinical suspicion and a thorough occupational and environmental history are essential for accurate diagnosis. There is no single pathognomonic feature for HP, rather, diagnosis relies on a constellation of clinical, radiologic, and pathologic findings. The radiologic manifestations, particularly the high-resolution computed tomography (HRCT) pattern, provide important clues and frequently point clinicians towards the correct diagnosis. The HRCT findings in HP may include ground-glass opacification, centrilobular nodules, air trapping (mosaic pattern), fibrosis, emphysema, or more frequently a combination of these. The combination of a mosaic pattern with ground-glass opacification and centrilobular nodules is particularly suggestive of the diagnosis. The best long-term prognosis is achieved with early diagnosis and removal from exposure.
AB - Hypersensitivity pneumonitis (HP) is an inflammatory interstitial lung disease caused by recurring exposure to a variety of occupational and environmental antigens. It features widely variable clinical, radiologic, and histopathologic findings. Because the clinical findings of HP mimic multiple other diseases, a high degree of clinical suspicion and a thorough occupational and environmental history are essential for accurate diagnosis. There is no single pathognomonic feature for HP, rather, diagnosis relies on a constellation of clinical, radiologic, and pathologic findings. The radiologic manifestations, particularly the high-resolution computed tomography (HRCT) pattern, provide important clues and frequently point clinicians towards the correct diagnosis. The HRCT findings in HP may include ground-glass opacification, centrilobular nodules, air trapping (mosaic pattern), fibrosis, emphysema, or more frequently a combination of these. The combination of a mosaic pattern with ground-glass opacification and centrilobular nodules is particularly suggestive of the diagnosis. The best long-term prognosis is achieved with early diagnosis and removal from exposure.
KW - Bioaerosols
KW - Extrinsic allergic alveolitis
KW - Granuloma
KW - Hypersensitivity pneumonitis
UR - http://www.scopus.com/inward/record.url?scp=0036790901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036790901&partnerID=8YFLogxK
U2 - 10.1097/00005382-200210000-00003
DO - 10.1097/00005382-200210000-00003
M3 - Article
C2 - 12362065
AN - SCOPUS:0036790901
VL - 17
SP - 261
EP - 272
JO - Journal of Thoracic Imaging
JF - Journal of Thoracic Imaging
SN - 0883-5993
IS - 4
ER -