Clinical application and limitations of the fluorescence in situ hybridization (FISH) assay in the diagnosis and management of melanocytic lesions, a report of 3 cases

Rajiv I. Nijhawan, Henry J. Votava, Kavita Mariwalla

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Histopathologic examination is the gold standard for the diagnosis of melanocytic lesions, including melanoma, and guides management options and disease prognosis based on the depth of invasion. Although most melanomas can be readily distinguished from benign nevi, some pigmented lesions are more ambiguous and can be challenging to interpret as truly benign or truly malignant. Unfortunately, misclassification can render severe consequences for the patient, making it imperative to explore further analysis to determine the true nature of an ambiguous lesion. A relatively new technique known as fluorescence in situ hybridization (FISH) has become prevalent in dermatopathology for distinguishing between benign and malignant pigmented lesions, however, there are few reports on the application of FISH results in the clinical setting. We present 3 cases in which a FISH assay was utilized to assist in the diagnosis and management of ambiguous pigmented lesions. We also provide a review of the most recent literature regarding this diagnostic modality.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalCutis
Volume90
Issue number4
StatePublished - 2012

Fingerprint

Fluorescence In Situ Hybridization
Melanoma
Pigmented Nevus
Disease Management

ASJC Scopus subject areas

  • Dermatology

Cite this

Clinical application and limitations of the fluorescence in situ hybridization (FISH) assay in the diagnosis and management of melanocytic lesions, a report of 3 cases. / Nijhawan, Rajiv I.; Votava, Henry J.; Mariwalla, Kavita.

In: Cutis, Vol. 90, No. 4, 2012, p. 189-195.

Research output: Contribution to journalArticle

@article{b960bb5164d54071aa9cce4af0bc5b3e,
title = "Clinical application and limitations of the fluorescence in situ hybridization (FISH) assay in the diagnosis and management of melanocytic lesions, a report of 3 cases",
abstract = "Histopathologic examination is the gold standard for the diagnosis of melanocytic lesions, including melanoma, and guides management options and disease prognosis based on the depth of invasion. Although most melanomas can be readily distinguished from benign nevi, some pigmented lesions are more ambiguous and can be challenging to interpret as truly benign or truly malignant. Unfortunately, misclassification can render severe consequences for the patient, making it imperative to explore further analysis to determine the true nature of an ambiguous lesion. A relatively new technique known as fluorescence in situ hybridization (FISH) has become prevalent in dermatopathology for distinguishing between benign and malignant pigmented lesions, however, there are few reports on the application of FISH results in the clinical setting. We present 3 cases in which a FISH assay was utilized to assist in the diagnosis and management of ambiguous pigmented lesions. We also provide a review of the most recent literature regarding this diagnostic modality.",
author = "Nijhawan, {Rajiv I.} and Votava, {Henry J.} and Kavita Mariwalla",
year = "2012",
language = "English (US)",
volume = "90",
pages = "189--195",
journal = "Cutis",
issn = "0011-4162",
publisher = "Quadrant Healthcom Inc.",
number = "4",

}

TY - JOUR

T1 - Clinical application and limitations of the fluorescence in situ hybridization (FISH) assay in the diagnosis and management of melanocytic lesions, a report of 3 cases

AU - Nijhawan, Rajiv I.

AU - Votava, Henry J.

AU - Mariwalla, Kavita

PY - 2012

Y1 - 2012

N2 - Histopathologic examination is the gold standard for the diagnosis of melanocytic lesions, including melanoma, and guides management options and disease prognosis based on the depth of invasion. Although most melanomas can be readily distinguished from benign nevi, some pigmented lesions are more ambiguous and can be challenging to interpret as truly benign or truly malignant. Unfortunately, misclassification can render severe consequences for the patient, making it imperative to explore further analysis to determine the true nature of an ambiguous lesion. A relatively new technique known as fluorescence in situ hybridization (FISH) has become prevalent in dermatopathology for distinguishing between benign and malignant pigmented lesions, however, there are few reports on the application of FISH results in the clinical setting. We present 3 cases in which a FISH assay was utilized to assist in the diagnosis and management of ambiguous pigmented lesions. We also provide a review of the most recent literature regarding this diagnostic modality.

AB - Histopathologic examination is the gold standard for the diagnosis of melanocytic lesions, including melanoma, and guides management options and disease prognosis based on the depth of invasion. Although most melanomas can be readily distinguished from benign nevi, some pigmented lesions are more ambiguous and can be challenging to interpret as truly benign or truly malignant. Unfortunately, misclassification can render severe consequences for the patient, making it imperative to explore further analysis to determine the true nature of an ambiguous lesion. A relatively new technique known as fluorescence in situ hybridization (FISH) has become prevalent in dermatopathology for distinguishing between benign and malignant pigmented lesions, however, there are few reports on the application of FISH results in the clinical setting. We present 3 cases in which a FISH assay was utilized to assist in the diagnosis and management of ambiguous pigmented lesions. We also provide a review of the most recent literature regarding this diagnostic modality.

UR - http://www.scopus.com/inward/record.url?scp=84872102343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872102343&partnerID=8YFLogxK

M3 - Article

C2 - 23259206

AN - SCOPUS:84872102343

VL - 90

SP - 189

EP - 195

JO - Cutis

JF - Cutis

SN - 0011-4162

IS - 4

ER -