Clinical applications of advanced lipoprotein testing in diabetes mellitus

Danyaal S. Moin, Anand Rohatgi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Traditional lipid profiles often fail to fully explain the elevated cardiovascular risk of individuals with diabetes mellitus. Advanced lipoprotein testing offers a novel means to evaluate dyslipidemia and refine risk estimation. Numerous observational studies have demonstrated a characteristic pattern of elevated levels of small, dense LDL particles, out of proportion to traditional lipid levels, in patients with both diabetes mellitus and the metabolic syndrome. Commonly used glucose and lipid-lowering agents have varied effects in patients with diabetes on both LDL and HDL subfractions. The exact role of advanced lipoprotein testing in patients with diabetes mellitus and the metabolic syndrome remains unclear but may offer improved assessment of cardiovascular risk compared with traditional lipid measurements.

Original languageEnglish (US)
Pages (from-to)371-387
Number of pages17
JournalClinical Lipidology
Volume6
Issue number4
DOIs
StatePublished - Aug 2011

Fingerprint

Lipoproteins
Diabetes Mellitus
Lipids
Dyslipidemias
Observational Studies
Glucose
oxidized low density lipoprotein

Keywords

  • diabetes
  • lipoprotein
  • metabolic syndrome
  • particles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Clinical applications of advanced lipoprotein testing in diabetes mellitus. / Moin, Danyaal S.; Rohatgi, Anand.

In: Clinical Lipidology, Vol. 6, No. 4, 08.2011, p. 371-387.

Research output: Contribution to journalArticle

@article{b9c7eb5e74964691a9ad0c822f658ba3,
title = "Clinical applications of advanced lipoprotein testing in diabetes mellitus",
abstract = "Traditional lipid profiles often fail to fully explain the elevated cardiovascular risk of individuals with diabetes mellitus. Advanced lipoprotein testing offers a novel means to evaluate dyslipidemia and refine risk estimation. Numerous observational studies have demonstrated a characteristic pattern of elevated levels of small, dense LDL particles, out of proportion to traditional lipid levels, in patients with both diabetes mellitus and the metabolic syndrome. Commonly used glucose and lipid-lowering agents have varied effects in patients with diabetes on both LDL and HDL subfractions. The exact role of advanced lipoprotein testing in patients with diabetes mellitus and the metabolic syndrome remains unclear but may offer improved assessment of cardiovascular risk compared with traditional lipid measurements.",
keywords = "diabetes, lipoprotein, metabolic syndrome, particles",
author = "Moin, {Danyaal S.} and Anand Rohatgi",
year = "2011",
month = "8",
doi = "10.2217/clp.11.37",
language = "English (US)",
volume = "6",
pages = "371--387",
journal = "Clinical Lipidology",
issn = "1758-4299",
publisher = "Future Medicine Ltd.",
number = "4",

}

TY - JOUR

T1 - Clinical applications of advanced lipoprotein testing in diabetes mellitus

AU - Moin, Danyaal S.

AU - Rohatgi, Anand

PY - 2011/8

Y1 - 2011/8

N2 - Traditional lipid profiles often fail to fully explain the elevated cardiovascular risk of individuals with diabetes mellitus. Advanced lipoprotein testing offers a novel means to evaluate dyslipidemia and refine risk estimation. Numerous observational studies have demonstrated a characteristic pattern of elevated levels of small, dense LDL particles, out of proportion to traditional lipid levels, in patients with both diabetes mellitus and the metabolic syndrome. Commonly used glucose and lipid-lowering agents have varied effects in patients with diabetes on both LDL and HDL subfractions. The exact role of advanced lipoprotein testing in patients with diabetes mellitus and the metabolic syndrome remains unclear but may offer improved assessment of cardiovascular risk compared with traditional lipid measurements.

AB - Traditional lipid profiles often fail to fully explain the elevated cardiovascular risk of individuals with diabetes mellitus. Advanced lipoprotein testing offers a novel means to evaluate dyslipidemia and refine risk estimation. Numerous observational studies have demonstrated a characteristic pattern of elevated levels of small, dense LDL particles, out of proportion to traditional lipid levels, in patients with both diabetes mellitus and the metabolic syndrome. Commonly used glucose and lipid-lowering agents have varied effects in patients with diabetes on both LDL and HDL subfractions. The exact role of advanced lipoprotein testing in patients with diabetes mellitus and the metabolic syndrome remains unclear but may offer improved assessment of cardiovascular risk compared with traditional lipid measurements.

KW - diabetes

KW - lipoprotein

KW - metabolic syndrome

KW - particles

UR - http://www.scopus.com/inward/record.url?scp=80051992741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051992741&partnerID=8YFLogxK

U2 - 10.2217/clp.11.37

DO - 10.2217/clp.11.37

M3 - Article

C2 - 22162979

AN - SCOPUS:80051992741

VL - 6

SP - 371

EP - 387

JO - Clinical Lipidology

JF - Clinical Lipidology

SN - 1758-4299

IS - 4

ER -