Clinical applications of advanced lipoprotein testing in diabetes mellitus

Danyaal S. Moin, Anand Rohatgi

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Traditional lipid profiles often fail to fully explain the elevated cardiovascular risk of individuals with diabetes mellitus. Advanced lipoprotein testing offers a novel means to evaluate dyslipidemia and refine risk estimation. Numerous observational studies have demonstrated a characteristic pattern of elevated levels of small, dense LDL particles, out of proportion to traditional lipid levels, in patients with both diabetes mellitus and the metabolic syndrome. Commonly used glucose and lipid-lowering agents have varied effects in patients with diabetes on both LDL and HDL subfractions. The exact role of advanced lipoprotein testing in patients with diabetes mellitus and the metabolic syndrome remains unclear but may offer improved assessment of cardiovascular risk compared with traditional lipid measurements.

Original languageEnglish (US)
Pages (from-to)371-387
Number of pages17
JournalClinical Lipidology
Volume6
Issue number4
DOIs
StatePublished - Aug 1 2011

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Keywords

  • diabetes
  • lipoprotein
  • metabolic syndrome
  • particles

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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