TY - JOUR
T1 - Clinical complications of oral contraceptives.
AU - Kaplan, Norman M
N1 - Funding Information:
A portion of the material in this review was obtained from research studies supported by a contract (NIH 69-2250) from the National Institute of Child Health and Human Development to Duke University Medical Center.
Funding Information:
is Professor of Neurology at Duke University Medical Center and Director of the Duke-V.A. Center for Cerebrovascular Research. After graduation from the University of Maryland School of Medicine, he took his post-graduate training at Grady Hospital, Atlanta, Georgia. Doctor Heyman is a member of the American Neurological Association and a Fellow of the American Academy of Neurology. A recipient of the Research Career Award from the National Institute of Neurologic Diseases and Stroke, his principal investigative interests a~e in the field of cerebrovascular disease.
PY - 1975
Y1 - 1975
N2 - Reports of complications due to estrogen-progestagen combinations are summarized. Common minor symptoms include nausea, abdominal distress, headache, depression, and weight gain. Some of these are directly due to the pill, but others are not; for instance, depression may result from pyrodoxine deficiency, but psychodynamic factors explain the problem in others. Effects on the reproductive organs include secondary amenorrhea in about 2 of every 1000 women; structural and functional changes of the ovaries, uterus, and cervix; increase in incidence of yeast vulvovaginitis; and inhibition of lactation. Most changes in laboratory values of various constituents of blood and other body fluids reflect changes in hepatic function. Thromboembolic diseases, hypertension, and hypertriglyceridemia are rare but more serious conditions for which the pill may be responsible in some cases. Contribution of the pill to carcinogenesis and fetal abnormalities has not been proven.
AB - Reports of complications due to estrogen-progestagen combinations are summarized. Common minor symptoms include nausea, abdominal distress, headache, depression, and weight gain. Some of these are directly due to the pill, but others are not; for instance, depression may result from pyrodoxine deficiency, but psychodynamic factors explain the problem in others. Effects on the reproductive organs include secondary amenorrhea in about 2 of every 1000 women; structural and functional changes of the ovaries, uterus, and cervix; increase in incidence of yeast vulvovaginitis; and inhibition of lactation. Most changes in laboratory values of various constituents of blood and other body fluids reflect changes in hepatic function. Thromboembolic diseases, hypertension, and hypertriglyceridemia are rare but more serious conditions for which the pill may be responsible in some cases. Contribution of the pill to carcinogenesis and fetal abnormalities has not been proven.
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M3 - Review article
C2 - 1090118
AN - SCOPUS:0016410264
VL - 20
SP - 197
EP - 214
JO - Advances in Internal Medicine
JF - Advances in Internal Medicine
SN - 0065-2822
ER -