Clinical consequences of mutations in sodium phosphate cotransporters

Eleanor Lederer, Ken ichi Miyamoto

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Three families of sodium phosphate cotransporters have been described. Their specific roles in human health and disease have not been defined. Review of the literature reveals that the type II sodium phosphate cotransporters play a significant role in transepithelial transport in a number of tissues including kidney, intestine, salivary gland, mammary gland, and lung. The type I transporters seemto play amajor role in renal urate handling andmutations in these proteins have been implicated in susceptibility to gout. The ubiquitously expressed type III transporters play a lesser role in phosphate homeostasis but contribute to cellular phosphate uptake, mineralization, and inflammation. The recognition of species differences in the expression, regulation, and function of these transport proteins suggests an urgent need to find ways to study them in humans.

Original languageEnglish (US)
Pages (from-to)1179-1187
Number of pages9
JournalClinical Journal of the American Society of Nephrology
Volume7
Issue number7
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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