Clinical consequences of the autonomic imbalance in hypertension and congestive heart failure

Stevo Julius, Shawna Nesbitt

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The reduction of coronary mortality is not as large as one would expect from the observed blood pressure lowering in trials of antihypertensive medications. This is not surprising; hypertension is a complex disease where the high blood pressure is only one of numerous coronary risk factors. Sympathetic overactivity in hypertension, independent of the blood pressure, may be conducive to premature atherosclerosis by inducing insulin resistance and dyslipidemia. Through its trophic effect on blood vessels, sympathetic overactivity potentiates vasoconstriction. This, in turn, accelerates hypertension and the metabolic syndrome. The hypertrophy of small coronary arterioles decreases the coronary reserve and enhances coronary spasms. Tachycardia, which is due to increased sympathetic tone and a decreased parasympathetic tone, favors arrhythmias and sudden death in congestive heart failure and hypertension. Increased hematocrit is frequently found in male patients with hypertension, and high hematocrit is a predictor of coronary heart disease/thrombosis. The increase of hematocrit is in part due to an alpha adrenergic postcapillary venoconstriction. Enhanced sympathetic drive, insulin resistance and dyslipidemia have been demonstrated also in congestive heart failure, but the clinical importance of these findings is not fully understood.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalScandinavian Cardiovascular Journal, Supplement
Volume32
Issue number47
StatePublished - 1998

Fingerprint

Heart Failure
Hypertension
Hematocrit
Dyslipidemias
Insulin Resistance
Blood Pressure
Spasm
Arterioles
Sudden Death
Vasoconstriction
Tachycardia
Adrenergic Agents
Hypertrophy
Antihypertensive Agents
Coronary Disease
Blood Vessels
Cardiac Arrhythmias
Atherosclerosis
Thrombosis
Mortality

Keywords

  • Cardiovascular risk
  • Hematocrit
  • Parasympathetic tone
  • Sympathetic tone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Clinical consequences of the autonomic imbalance in hypertension and congestive heart failure. / Julius, Stevo; Nesbitt, Shawna.

In: Scandinavian Cardiovascular Journal, Supplement, Vol. 32, No. 47, 1998, p. 23-30.

Research output: Contribution to journalArticle

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