TY - JOUR
T1 - Clinical correlates of steady-state oxyhaemoglobin desaturation in children who have sickle cell disease
AU - Quinn, Charles T.
AU - Ahmad, Naveed
PY - 2005/10
Y1 - 2005/10
N2 - Individuals with sickle cell disease (SCD) may have oxyhaemoglobin desaturation during the steady-state, the causes of which are incompletely known. We studied a cohort of 585 children who have sickle cell anaemia (SS), sickle β0-thalassaemia (Sβ0), sickle-haemoglobin C disease (SC), or sickle β+-thalassaemia (Sβ+) to determine the relationships between steady-state oxyhaemoglobin saturation (SpO2) and SCD genotype, age, gender, steady-state haemoglobin (Hb) and reticulocyte count, and rate of acute chest syndrome (ACS). The SS/Sβ0 group (n = 390) had lower mean SpO2 than the SC/Sβ+ group (n = 195) (96.3% vs. 98.7%, P < 0.001). Among SS/Sβ0 subjects, a decrease in steady-state SpO2 correlated with a decrease in Hb, an increase in reticulocytes, older age and male gender. These correlations were not found in the SC/Sβ+ group. Prior ACS did not correlate with steady-state SpO2. A multivariate model explained 45% of the variability in SpO2, but only 5% of the variation in SpO2 was explained by Hb. We conclude that steady-state desaturation is common in individuals with SCD, but it appears to be unrelated to prior episodes of ACS and largely unexplained by chronic anaemia.
AB - Individuals with sickle cell disease (SCD) may have oxyhaemoglobin desaturation during the steady-state, the causes of which are incompletely known. We studied a cohort of 585 children who have sickle cell anaemia (SS), sickle β0-thalassaemia (Sβ0), sickle-haemoglobin C disease (SC), or sickle β+-thalassaemia (Sβ+) to determine the relationships between steady-state oxyhaemoglobin saturation (SpO2) and SCD genotype, age, gender, steady-state haemoglobin (Hb) and reticulocyte count, and rate of acute chest syndrome (ACS). The SS/Sβ0 group (n = 390) had lower mean SpO2 than the SC/Sβ+ group (n = 195) (96.3% vs. 98.7%, P < 0.001). Among SS/Sβ0 subjects, a decrease in steady-state SpO2 correlated with a decrease in Hb, an increase in reticulocytes, older age and male gender. These correlations were not found in the SC/Sβ+ group. Prior ACS did not correlate with steady-state SpO2. A multivariate model explained 45% of the variability in SpO2, but only 5% of the variation in SpO2 was explained by Hb. We conclude that steady-state desaturation is common in individuals with SCD, but it appears to be unrelated to prior episodes of ACS and largely unexplained by chronic anaemia.
KW - Children
KW - Hypoxaemia
KW - Pulse oximetry
KW - Sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=27744562780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744562780&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.2005.05738.x
DO - 10.1111/j.1365-2141.2005.05738.x
M3 - Article
C2 - 16173973
AN - SCOPUS:27744562780
VL - 131
SP - 129
EP - 134
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -