Clinical correlations of diffusion and perfusion lesion volumes in acute ischemic stroke

Alison E. Baird, Karl Olof Lövblad, John F. Dashe, Ann Connor, Cara Burzynski, Gottfried Schlaug, Irina Straroselskaya, Robert R. Edelman, Steven Warach

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


The aim of this study was to describe the clinico-radiological correlations of magnetic resonance (MR) perfusion and diffusion-weighted imaging (DWI) abnormalities in ischemic stroke. Eighteen patients had undergone MR imaging and clinical evaluation within 24 h of symptom onset and at or after 7 days. During the first 24 h the volume of perfusion abnormality (measured on the relative mean transit time map) was larger than the DWI lesion in 12/18 patients. In 6/18 patients the DWI lesion volume was larger. Acutely (<24 h) all lesion volumes showed a significant correlation with acute clinical severity measured by the National Institutes of Health Stroke Scale score. The correlations of the hypoperfusion volume (rho = 0.86, p = 0.0001) and the volume 'tissue at risk' (larger than the DWI and perfusion lesion volumes, rho = 0.86, p = 0.0001) with acute clinical severity were slightly higher than for the DWI lesion volume (rho = 0.76, p = 0.0001). The difference between the volume of tissue at risk (acutely) and the infarct on follow-up T2-weighted imaging correlated significantly with change in clinical severity from acute to chronic time points (rho = 0.72, p = 0.001). Such clinico-radiological relationships may support the use of DWI and perfusion MR in decisions concerning the administration and evaluation of stroke therapies. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)441-448
Number of pages8
JournalCerebrovascular Diseases
Issue number6
StatePublished - 2000


  • Cerebrovascular disorders
  • Diffusion-weighted imaging
  • Ischemic stroke
  • Magnetic resonance
  • Perfusion
  • Stroke outcome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Clinical correlations of diffusion and perfusion lesion volumes in acute ischemic stroke'. Together they form a unique fingerprint.

Cite this