Clinical differences among depressed patients with and without a history of suicide attempts: Findings from the STAR*D trial

Cynthia A. Claassen, Madhukar H. Trivedi, A. John Rush, Mustafa M. Husain, Sidney Zisook, Elizabeth Young, Andrew Leuchter, Stephen R. Wisniewski, G. K. Balasubramani, Jonathan Alpert

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: This study sought to determine whether a history of suicide attempts among outpatients diagnosed with nonpsychotic major depressive disorder (MDD) is correlated with any difference in clinical presentation that should influence patient care. Methods: Baseline data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial on outpatients with MDD treated in primary and specialty care settings were used to model significant demographic and clinical correlates of suicide attempter status. Results: Altogether, 16.5% of participants (n = 667) reported prior suicide attempts. Controlling for age, gender, and depressive symptom severity, previous attempters had more current general medical conditions (μ = 3.2 vs. 2.9, p < .0001), more current alcohol/substance abuse (p < .0001), and more work hours missed in the past week (26.2% vs. 18.2%, p < .0001) than non-attempters. On average, for the previously suicidal, the onset of MDD occurred 8.9 years earlier in life (p < .0001) and had included 1.2 additional depressive episodes (p = 0.001) compared to those without prior suicidal behavior. Previous attempters also reported more current suicidal ideation (61.3% of previous attempters, adjusted OR 1.6, vs. 45.5% of nonattempters, p < .0001). Limitations: Presence or absence of a history of suicide attempts was determined only through self report. Conclusions: Those with a history of suicidal behavior suffer a greater burden of depressive illness. Earlier intervention and ongoing, aggressive care, including maintenance-phase pharmacotherapy, may be critical to mitigating the long-term consequences associated with this increased disease burden.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalJournal of Affective Disorders
Volume97
Issue number1-3
DOIs
StatePublished - Jan 2007

Fingerprint

Suicide
Major Depressive Disorder
Depression
Outpatients
Suicidal Ideation
Cost of Illness
Therapeutics
Self Report
Alcoholism
Substance-Related Disorders
Primary Health Care
Patient Care
Maintenance
Demography
Drug Therapy

Keywords

  • Clinical features
  • Depression
  • Suicide
  • Suicide attempts

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Clinical differences among depressed patients with and without a history of suicide attempts : Findings from the STAR*D trial. / Claassen, Cynthia A.; Trivedi, Madhukar H.; Rush, A. John; Husain, Mustafa M.; Zisook, Sidney; Young, Elizabeth; Leuchter, Andrew; Wisniewski, Stephen R.; Balasubramani, G. K.; Alpert, Jonathan.

In: Journal of Affective Disorders, Vol. 97, No. 1-3, 01.2007, p. 77-84.

Research output: Contribution to journalArticle

Claassen, Cynthia A. ; Trivedi, Madhukar H. ; Rush, A. John ; Husain, Mustafa M. ; Zisook, Sidney ; Young, Elizabeth ; Leuchter, Andrew ; Wisniewski, Stephen R. ; Balasubramani, G. K. ; Alpert, Jonathan. / Clinical differences among depressed patients with and without a history of suicide attempts : Findings from the STAR*D trial. In: Journal of Affective Disorders. 2007 ; Vol. 97, No. 1-3. pp. 77-84.
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abstract = "Background: This study sought to determine whether a history of suicide attempts among outpatients diagnosed with nonpsychotic major depressive disorder (MDD) is correlated with any difference in clinical presentation that should influence patient care. Methods: Baseline data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial on outpatients with MDD treated in primary and specialty care settings were used to model significant demographic and clinical correlates of suicide attempter status. Results: Altogether, 16.5{\%} of participants (n = 667) reported prior suicide attempts. Controlling for age, gender, and depressive symptom severity, previous attempters had more current general medical conditions (μ = 3.2 vs. 2.9, p < .0001), more current alcohol/substance abuse (p < .0001), and more work hours missed in the past week (26.2{\%} vs. 18.2{\%}, p < .0001) than non-attempters. On average, for the previously suicidal, the onset of MDD occurred 8.9 years earlier in life (p < .0001) and had included 1.2 additional depressive episodes (p = 0.001) compared to those without prior suicidal behavior. Previous attempters also reported more current suicidal ideation (61.3{\%} of previous attempters, adjusted OR 1.6, vs. 45.5{\%} of nonattempters, p < .0001). Limitations: Presence or absence of a history of suicide attempts was determined only through self report. Conclusions: Those with a history of suicidal behavior suffer a greater burden of depressive illness. Earlier intervention and ongoing, aggressive care, including maintenance-phase pharmacotherapy, may be critical to mitigating the long-term consequences associated with this increased disease burden.",
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T1 - Clinical differences among depressed patients with and without a history of suicide attempts

T2 - Findings from the STAR*D trial

AU - Claassen, Cynthia A.

AU - Trivedi, Madhukar H.

AU - Rush, A. John

AU - Husain, Mustafa M.

AU - Zisook, Sidney

AU - Young, Elizabeth

AU - Leuchter, Andrew

AU - Wisniewski, Stephen R.

AU - Balasubramani, G. K.

AU - Alpert, Jonathan

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N2 - Background: This study sought to determine whether a history of suicide attempts among outpatients diagnosed with nonpsychotic major depressive disorder (MDD) is correlated with any difference in clinical presentation that should influence patient care. Methods: Baseline data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial on outpatients with MDD treated in primary and specialty care settings were used to model significant demographic and clinical correlates of suicide attempter status. Results: Altogether, 16.5% of participants (n = 667) reported prior suicide attempts. Controlling for age, gender, and depressive symptom severity, previous attempters had more current general medical conditions (μ = 3.2 vs. 2.9, p < .0001), more current alcohol/substance abuse (p < .0001), and more work hours missed in the past week (26.2% vs. 18.2%, p < .0001) than non-attempters. On average, for the previously suicidal, the onset of MDD occurred 8.9 years earlier in life (p < .0001) and had included 1.2 additional depressive episodes (p = 0.001) compared to those without prior suicidal behavior. Previous attempters also reported more current suicidal ideation (61.3% of previous attempters, adjusted OR 1.6, vs. 45.5% of nonattempters, p < .0001). Limitations: Presence or absence of a history of suicide attempts was determined only through self report. Conclusions: Those with a history of suicidal behavior suffer a greater burden of depressive illness. Earlier intervention and ongoing, aggressive care, including maintenance-phase pharmacotherapy, may be critical to mitigating the long-term consequences associated with this increased disease burden.

AB - Background: This study sought to determine whether a history of suicide attempts among outpatients diagnosed with nonpsychotic major depressive disorder (MDD) is correlated with any difference in clinical presentation that should influence patient care. Methods: Baseline data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial on outpatients with MDD treated in primary and specialty care settings were used to model significant demographic and clinical correlates of suicide attempter status. Results: Altogether, 16.5% of participants (n = 667) reported prior suicide attempts. Controlling for age, gender, and depressive symptom severity, previous attempters had more current general medical conditions (μ = 3.2 vs. 2.9, p < .0001), more current alcohol/substance abuse (p < .0001), and more work hours missed in the past week (26.2% vs. 18.2%, p < .0001) than non-attempters. On average, for the previously suicidal, the onset of MDD occurred 8.9 years earlier in life (p < .0001) and had included 1.2 additional depressive episodes (p = 0.001) compared to those without prior suicidal behavior. Previous attempters also reported more current suicidal ideation (61.3% of previous attempters, adjusted OR 1.6, vs. 45.5% of nonattempters, p < .0001). Limitations: Presence or absence of a history of suicide attempts was determined only through self report. Conclusions: Those with a history of suicidal behavior suffer a greater burden of depressive illness. Earlier intervention and ongoing, aggressive care, including maintenance-phase pharmacotherapy, may be critical to mitigating the long-term consequences associated with this increased disease burden.

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