Clinical experience of seropositive ganglionic acetylcholine receptor antibody in a tertiary neurology referral center

Yuebing Li, Adham Jammoul, Karin Mente, Jianbo Li, Robert W. Shields, Steven Vernino, Alexander Rae-Grant

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Introduction: Antibody against the acetylcholine receptor of autonomic ganglia (gAChR-Ab) is implicated in the pathogenesis of autoimmune autonomic ganglionopathy (AAG) and several other disorders. Methods: This study was a retrospective evaluation of 95 patients positive for gAChR-Ab. Results: Twenty-one (22%) patients had AAG, with a greater median gAChR-Ab level (0.21 nmol/L) and higher percentage (57%) of antibody levels >0.20 nmol/L when compared with the remaining 74 patients without autonomic manifestations (non-AAG group, 0.10 nmol/L and 15%, respectively). Only 2 new cases of malignancy were diagnosed after gAChR-Ab detection. The non-AAG group was associated with high frequencies of neurological and non-neurological autoimmunity, but also included 23 (31%) patients with mostly degenerative disorders. Conclusion: Detection of gAChR-Ab, especially at a higher level, is helpful for the diagnosis of AAG in patients with corresponding autonomic symptoms. However, its value is limited for predicting cancer risk and for diagnosis and management of patients without autonomic symptoms.

Original languageEnglish (US)
Pages (from-to)386-391
Number of pages6
JournalMuscle and Nerve
Volume52
Issue number3
DOIs
StatePublished - Sep 1 2015

Keywords

  • Autoimmune autonomic ganglionopathy
  • Autoimmunity
  • Diagnostic testing
  • Ganglionic autonomic acetylcholine receptor
  • Malignancy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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