Until recently, chronic lymphocytic leukemia (CLL) was thought to be a single entity with a variable history. All patients received essentially the same types of treatment. With the advent of immunology, however, several different subsets of lymphocytes have been detected. These subsets are also factors in CLL, which is now known to have several forms. The background has thus been set for trials of therapy aimed at the form of CLL present and, in the case of B-cell CLL, the most common form, also at the stage of disease.
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