Clinical, histologic, microbiologic, and biochemical characterization of the causative agent of bacillary (epithelioid) angiomatosis: A rickettsial illness with features of bartonellosis

Clay J. Cockerell, Philip M. Tierno, Alvin E. Friedman-Kien, Kwang S. Kim

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Abstract

It has been suggested that bacillary (epithelioid) angiomatosis (BEA) is a manifestation of cat scratch disease (CSD). Because of clinical similarity between this condition and the verruga peruana phase of bartonellosis, we sought to further characterize this disease as well as its causative agent and to compare it to bartonellosis. We isolated a small flagellated pleomorphic bacillus from skin lesions of two patients with BEA. Organisms were stained successfully with Warthin-Starry silver stains, but immunohistochemistry failed to demonstrate binding with a polyclonal antibody directed against the cat scratch bacillus. Whole cell fatty-acid gas chromatography performed on both BEA organisms and Bartonella bacilliformis demonstrated marked similarity between the two. Electron microscopy of BEA organisms in tissue and in suspension revealed features characteristic of a gram negative bacillus. Based on these findings, we propose that this unusual rickettsial infectious disease with vascular proliferation may represent an unusual variant of infection with a bartonella-like organism rather than a manifestation of cat scratch disease.

Original languageEnglish (US)
Pages (from-to)812-817
Number of pages6
JournalJournal of Investigative Dermatology
Volume97
Issue number5
StatePublished - Nov 1991

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Bacillary Angiomatosis
Bartonella Infections
Cat-Scratch Disease
Bacillus
Bacilli
Bartonella bacilliformis
Bartonella
Silver
Gas Chromatography
Communicable Diseases
Blood Vessels
Suspensions
Electron Microscopy
Cats
Coloring Agents
Fatty Acids
Immunohistochemistry
Gas chromatography
Electron microscopy
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Clinical, histologic, microbiologic, and biochemical characterization of the causative agent of bacillary (epithelioid) angiomatosis : A rickettsial illness with features of bartonellosis. / Cockerell, Clay J.; Tierno, Philip M.; Friedman-Kien, Alvin E.; Kim, Kwang S.

In: Journal of Investigative Dermatology, Vol. 97, No. 5, 11.1991, p. 812-817.

Research output: Contribution to journalArticle

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