Clinical, immunological and epidemiological aspects of strongyloidiasis in an endemic area of Brazil.

I. T. de Messias, F. Q. Telles, A. C. Boaretti, S. Sliva, L. M. Guimarres, R. M. Genta

Research output: Contribution to journalArticle

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Abstract

Eighty-eight residents of Curitiba, Brazil, with parasitologically proven Strongyloides stercoralis infection were assessed clinically and evaluated for their specific and non-specific responses to the parasite. A control group of 73 patients with other intestinal parasites, but with negative stools for S. stercoralis were also evaluated. Abdominal symptoms and/or weight loss were present in 24% of the patients with strongyloidiasis and in 25% of the patients with other parasites only. Elevated peripheral eosinophilia (greater than 5%) was present in 68% of the patients with strongyloidiasis (mean = 10.6%) and in 73% of the individuals with other parasites only (mean = 8.8%). Total serum IgE were elevated (greater than IU/ml) in 84% of the patients with strongyloidiasis (mean = 2872 IU/ml), and in 79% of the patients with other parasites only. Over 90% of the patients with proven strongyloidiasis had detectable levels of parasite specific IgG and IgE antibodies, as detected by the ELISA and the RAST, respectively. These antibodies were present in 23% of the individuals in whom fecal examinations had failed to reveal S. stercoralis. We conclude that in an endemic area, gastrointestinal manifestations and non-specific indicators of parasitic infections, such as elevated peripheral eosinophilia and total IgE, are not useful indexes of the presence of strongyloidiasis. Immunoserologic tests, such as the ELISA and the RAST may represent sensitive and specific tools for the screening of candidates for immunosuppression and for gathering needed epidemiological information about this increasingly important opportunistic nematode.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalAllergologia et Immunopathologia
Volume15
Issue number1
StatePublished - Jan 1987

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Strongyloidiasis
Brazil
Parasites
Strongyloides stercoralis
Immunoglobulin E
Eosinophilia
Enzyme-Linked Immunosorbent Assay
Parasitic Diseases
Antibodies
Immunosuppression
Weight Loss
Immunoglobulin G
Control Groups
Infection
Serum

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

de Messias, I. T., Telles, F. Q., Boaretti, A. C., Sliva, S., Guimarres, L. M., & Genta, R. M. (1987). Clinical, immunological and epidemiological aspects of strongyloidiasis in an endemic area of Brazil. Allergologia et Immunopathologia, 15(1), 37-41.

Clinical, immunological and epidemiological aspects of strongyloidiasis in an endemic area of Brazil. / de Messias, I. T.; Telles, F. Q.; Boaretti, A. C.; Sliva, S.; Guimarres, L. M.; Genta, R. M.

In: Allergologia et Immunopathologia, Vol. 15, No. 1, 01.1987, p. 37-41.

Research output: Contribution to journalArticle

de Messias, IT, Telles, FQ, Boaretti, AC, Sliva, S, Guimarres, LM & Genta, RM 1987, 'Clinical, immunological and epidemiological aspects of strongyloidiasis in an endemic area of Brazil.', Allergologia et Immunopathologia, vol. 15, no. 1, pp. 37-41.
de Messias, I. T. ; Telles, F. Q. ; Boaretti, A. C. ; Sliva, S. ; Guimarres, L. M. ; Genta, R. M. / Clinical, immunological and epidemiological aspects of strongyloidiasis in an endemic area of Brazil. In: Allergologia et Immunopathologia. 1987 ; Vol. 15, No. 1. pp. 37-41.
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abstract = "Eighty-eight residents of Curitiba, Brazil, with parasitologically proven Strongyloides stercoralis infection were assessed clinically and evaluated for their specific and non-specific responses to the parasite. A control group of 73 patients with other intestinal parasites, but with negative stools for S. stercoralis were also evaluated. Abdominal symptoms and/or weight loss were present in 24{\%} of the patients with strongyloidiasis and in 25{\%} of the patients with other parasites only. Elevated peripheral eosinophilia (greater than 5{\%}) was present in 68{\%} of the patients with strongyloidiasis (mean = 10.6{\%}) and in 73{\%} of the individuals with other parasites only (mean = 8.8{\%}). Total serum IgE were elevated (greater than IU/ml) in 84{\%} of the patients with strongyloidiasis (mean = 2872 IU/ml), and in 79{\%} of the patients with other parasites only. Over 90{\%} of the patients with proven strongyloidiasis had detectable levels of parasite specific IgG and IgE antibodies, as detected by the ELISA and the RAST, respectively. These antibodies were present in 23{\%} of the individuals in whom fecal examinations had failed to reveal S. stercoralis. We conclude that in an endemic area, gastrointestinal manifestations and non-specific indicators of parasitic infections, such as elevated peripheral eosinophilia and total IgE, are not useful indexes of the presence of strongyloidiasis. Immunoserologic tests, such as the ELISA and the RAST may represent sensitive and specific tools for the screening of candidates for immunosuppression and for gathering needed epidemiological information about this increasingly important opportunistic nematode.",
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