Clinical Mimics: An Emergency Medicine–Focused Review of Sepsis Mimics

Brit Long, Alex Koyfman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Sepsis is a common clinical condition, and mortality and morbidity may be severe. The current definition of sepsis involves systemic inflammatory response syndrome (SIRS) criteria, which is met by many conditions. Objective This review evaluates the SIRS continuum, signs and symptoms of sepsis, mimics of sepsis, and an approach to management for sepsis mimics. Discussion The current emergency medicine definition of sepsis includes SIRS, a definition that may be met by many conditions. Because of common pathophysiologic responses, these diseases present in a similar manner. These conditions include anaphylaxis, gastrointestinal emergency, pulmonary disease, metabolic abnormality, toxin ingestion/withdrawal, vasculitis, and spinal injury. Many of these conditions can be deadly if they are not diagnosed and managed. However, differentiating between sepsis and mimics can be difficult in the emergency setting. Laboratory abnormalities in isolation do not provide a definitive diagnosis. However, a combination of history, physical examination, and adjunctive studies may assist providers. For the patient in extremis, resuscitation must take precedence while attempts to differentiate sepsis from mimics are underway. Conclusions SIRS and sepsis exist along a continuum, with many other conditions overlapping because of a common physiologic response. A combination of factors will assist providers in differentiating sepsis from mimics rather than using diagnostic studies in isolation. Resuscitation should be initiated while attempting to differentiate sepsis from its mimics.

Original languageEnglish (US)
Pages (from-to)34-42
Number of pages9
JournalJournal of Emergency Medicine
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Sepsis
Emergencies
Systemic Inflammatory Response Syndrome
Resuscitation
Spinal Injuries
Emergency Medicine
Anaphylaxis
Vasculitis
Lung Diseases
Signs and Symptoms
Physical Examination
Eating
History
Morbidity
Mortality

Keywords

  • mimic
  • resuscitation
  • sepsis
  • septic shock
  • SIRS

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Clinical Mimics : An Emergency Medicine–Focused Review of Sepsis Mimics. / Long, Brit; Koyfman, Alex.

In: Journal of Emergency Medicine, Vol. 52, No. 1, 01.01.2017, p. 34-42.

Research output: Contribution to journalArticle

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