Clinical pharmacology of cefadroxil in infants and children

Ch M. Ginsburg, G. H. McCracken, J. C. Clahsen, M. L. Thomas

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The pharmacokinetics of cefadroxil suspension were studied in 30 children, 13 months to 12 years of age (mean age, 5.7 years). Average peak concentrations in serum of 11 to 14 μg/ml and of 7 to 10 μg/ml after 15- and 10-mg/kg doses, respectively, were not substantially affected by the feeding status. The serum half-life values were 1.3 to 1.5 h. Cefadroxil was detected in saliva of all children 2 h after 15-mg/kg doses: the levels ranged from 0.17 to 2.6 μg/ml (mean, 0.46 μg/ml). The average concentrations in urine were 1,700 and 2,620 μg/ml at 0 to 2 and 2 to 4 h, respectively, after 15-mg/kg doses. In a randomized controlled study of 50 children with impetigo, cefadroxil was as effective as penicillin G in curing existing lesions and in preventing development of new lesions. Cefadroxil may be useful for therapy of mucocutaneous and urinary tract infections in infants and children.

Original languageEnglish (US)
JournalInfection
Volume8
Issue number5 Supplement
DOIs
StatePublished - Sep 1980

Fingerprint

Cefadroxil
Clinical Pharmacology
Impetigo
Penicillin G
Serum
Saliva
Urinary Tract Infections
Half-Life
Suspensions
Pharmacokinetics
Urine

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

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Clinical pharmacology of cefadroxil in infants and children. / Ginsburg, Ch M.; McCracken, G. H.; Clahsen, J. C.; Thomas, M. L.

In: Infection, Vol. 8, No. 5 Supplement, 09.1980.

Research output: Contribution to journalArticle

Ginsburg, Ch M. ; McCracken, G. H. ; Clahsen, J. C. ; Thomas, M. L. / Clinical pharmacology of cefadroxil in infants and children. In: Infection. 1980 ; Vol. 8, No. 5 Supplement.
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