Clinical pharmacology of penicillin in newborn infants

William L. Nyhan, Harry C. Shirkey, George H. McCracken, Charles Ginsberg, Dale F. Chrane, Marion L. Thomas, Linda J. Horton

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The clinical pharmacology of penicillin was studied in 47 newborn infants. Serum dose-response curves were determined after intramuscular injection of penicillin G in doses of 16,650, 25,000, and 50,000 units per kilogram. Peak serum concentrations in infants under one week of age were 22 to 24.8 μg per milliliter after 16,650 and 25,000 units per kilogram per dose and 35.8 μg per milliliter after 50,000 units per kilogram per dose; antimicrobial activity was measurable for 8 to 12 hours. The halflife of penicillin in serum correlated inversely with age and clearance of creatinine and ranged from 3.2 hours in infants 0 to 6 days of age to 1.4 hours in infants 14 days of age or older. Excretion of penicillin in urine correlated directly with clearance of creatinine. Mean serum levels after a single daily intramuscular dose of 50,000 units per kilogram of procaine penicillin G to infants under one week of age were 7 to 8 μg per milliliter for 12 hours and 1.5 μg per milliliter at 24 hours after the dose.

Original languageEnglish (US)
Pages (from-to)692-698
Number of pages7
JournalThe Journal of Pediatrics
Volume82
Issue number4
DOIs
StatePublished - 1973

Fingerprint

Clinical Pharmacology
Penicillins
Newborn Infant
Serum
Creatinine
Penicillin G Procaine
Penicillin G
Intramuscular Injections
Half-Life
Urine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Nyhan, W. L., Shirkey, H. C., McCracken, G. H., Ginsberg, C., Chrane, D. F., Thomas, M. L., & Horton, L. J. (1973). Clinical pharmacology of penicillin in newborn infants. The Journal of Pediatrics, 82(4), 692-698. https://doi.org/10.1016/S0022-3476(73)80601-8

Clinical pharmacology of penicillin in newborn infants. / Nyhan, William L.; Shirkey, Harry C.; McCracken, George H.; Ginsberg, Charles; Chrane, Dale F.; Thomas, Marion L.; Horton, Linda J.

In: The Journal of Pediatrics, Vol. 82, No. 4, 1973, p. 692-698.

Research output: Contribution to journalArticle

Nyhan, WL, Shirkey, HC, McCracken, GH, Ginsberg, C, Chrane, DF, Thomas, ML & Horton, LJ 1973, 'Clinical pharmacology of penicillin in newborn infants', The Journal of Pediatrics, vol. 82, no. 4, pp. 692-698. https://doi.org/10.1016/S0022-3476(73)80601-8
Nyhan, William L. ; Shirkey, Harry C. ; McCracken, George H. ; Ginsberg, Charles ; Chrane, Dale F. ; Thomas, Marion L. ; Horton, Linda J. / Clinical pharmacology of penicillin in newborn infants. In: The Journal of Pediatrics. 1973 ; Vol. 82, No. 4. pp. 692-698.
@article{35cacdee29d747889b961862010e8121,
title = "Clinical pharmacology of penicillin in newborn infants",
abstract = "The clinical pharmacology of penicillin was studied in 47 newborn infants. Serum dose-response curves were determined after intramuscular injection of penicillin G in doses of 16,650, 25,000, and 50,000 units per kilogram. Peak serum concentrations in infants under one week of age were 22 to 24.8 μg per milliliter after 16,650 and 25,000 units per kilogram per dose and 35.8 μg per milliliter after 50,000 units per kilogram per dose; antimicrobial activity was measurable for 8 to 12 hours. The halflife of penicillin in serum correlated inversely with age and clearance of creatinine and ranged from 3.2 hours in infants 0 to 6 days of age to 1.4 hours in infants 14 days of age or older. Excretion of penicillin in urine correlated directly with clearance of creatinine. Mean serum levels after a single daily intramuscular dose of 50,000 units per kilogram of procaine penicillin G to infants under one week of age were 7 to 8 μg per milliliter for 12 hours and 1.5 μg per milliliter at 24 hours after the dose.",
author = "Nyhan, {William L.} and Shirkey, {Harry C.} and McCracken, {George H.} and Charles Ginsberg and Chrane, {Dale F.} and Thomas, {Marion L.} and Horton, {Linda J.}",
year = "1973",
doi = "10.1016/S0022-3476(73)80601-8",
language = "English (US)",
volume = "82",
pages = "692--698",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Clinical pharmacology of penicillin in newborn infants

AU - Nyhan, William L.

AU - Shirkey, Harry C.

AU - McCracken, George H.

AU - Ginsberg, Charles

AU - Chrane, Dale F.

AU - Thomas, Marion L.

AU - Horton, Linda J.

PY - 1973

Y1 - 1973

N2 - The clinical pharmacology of penicillin was studied in 47 newborn infants. Serum dose-response curves were determined after intramuscular injection of penicillin G in doses of 16,650, 25,000, and 50,000 units per kilogram. Peak serum concentrations in infants under one week of age were 22 to 24.8 μg per milliliter after 16,650 and 25,000 units per kilogram per dose and 35.8 μg per milliliter after 50,000 units per kilogram per dose; antimicrobial activity was measurable for 8 to 12 hours. The halflife of penicillin in serum correlated inversely with age and clearance of creatinine and ranged from 3.2 hours in infants 0 to 6 days of age to 1.4 hours in infants 14 days of age or older. Excretion of penicillin in urine correlated directly with clearance of creatinine. Mean serum levels after a single daily intramuscular dose of 50,000 units per kilogram of procaine penicillin G to infants under one week of age were 7 to 8 μg per milliliter for 12 hours and 1.5 μg per milliliter at 24 hours after the dose.

AB - The clinical pharmacology of penicillin was studied in 47 newborn infants. Serum dose-response curves were determined after intramuscular injection of penicillin G in doses of 16,650, 25,000, and 50,000 units per kilogram. Peak serum concentrations in infants under one week of age were 22 to 24.8 μg per milliliter after 16,650 and 25,000 units per kilogram per dose and 35.8 μg per milliliter after 50,000 units per kilogram per dose; antimicrobial activity was measurable for 8 to 12 hours. The halflife of penicillin in serum correlated inversely with age and clearance of creatinine and ranged from 3.2 hours in infants 0 to 6 days of age to 1.4 hours in infants 14 days of age or older. Excretion of penicillin in urine correlated directly with clearance of creatinine. Mean serum levels after a single daily intramuscular dose of 50,000 units per kilogram of procaine penicillin G to infants under one week of age were 7 to 8 μg per milliliter for 12 hours and 1.5 μg per milliliter at 24 hours after the dose.

UR - http://www.scopus.com/inward/record.url?scp=0015607416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015607416&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(73)80601-8

DO - 10.1016/S0022-3476(73)80601-8

M3 - Article

C2 - 4698343

AN - SCOPUS:0015607416

VL - 82

SP - 692

EP - 698

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 4

ER -