Clinical physiology: Skeletal muscle metabolites in patients with cardiogenic shock or severe congestive heart failure

J. Karlsson, J. T. Willerson, S. J. Leshin, C. B. Mullins, J. H. Mitchell

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Skeletal muscle metabolite concentrations were determined in 19 patients in either cardiogenic shock or severe left ventricular failure by obtaining a needle biopsy specimen of lateral thigh muscle. Evidence of anaerobic skeletal muscle metabolism was found in both patient groups with the greatest lactatc accumulation and most severe high-energy phosphate depletion present in the patients in cardiogenic shock. The skeletal muscle lactate accumulation was most pronounced in the patients that died. Blood lactate values did not absolutely predict skeletal muscle lactate concentrations in those patients in whom skeletal muscle lactate concentrations were the highest. The patients in cardiogenic shock and severe left ventricular failure who survived demonstrated a reduction in skeletal muscle lactate levels and a restoration of high-energy phosphates over several days which correlated with clinical and herno-dynamic improvement.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume35
Issue number1
DOIs
StatePublished - 1975

Fingerprint

Cardiogenic Shock
Physiology
Metabolites
Muscle
Skeletal Muscle
Heart Failure
Lactic Acid
Phosphates
Needle Biopsy
Thigh
Biopsy
Metabolism
Needles
Restoration
Blood
Muscles

Keywords

  • Cardiogenic shock
  • Congestive heart failure
  • Phosphates
  • Skeletal muscle high energy
  • Skeletal muscle lactate

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

@article{8595f19704f840caa6a2aef38e555855,
title = "Clinical physiology: Skeletal muscle metabolites in patients with cardiogenic shock or severe congestive heart failure",
abstract = "Skeletal muscle metabolite concentrations were determined in 19 patients in either cardiogenic shock or severe left ventricular failure by obtaining a needle biopsy specimen of lateral thigh muscle. Evidence of anaerobic skeletal muscle metabolism was found in both patient groups with the greatest lactatc accumulation and most severe high-energy phosphate depletion present in the patients in cardiogenic shock. The skeletal muscle lactate accumulation was most pronounced in the patients that died. Blood lactate values did not absolutely predict skeletal muscle lactate concentrations in those patients in whom skeletal muscle lactate concentrations were the highest. The patients in cardiogenic shock and severe left ventricular failure who survived demonstrated a reduction in skeletal muscle lactate levels and a restoration of high-energy phosphates over several days which correlated with clinical and herno-dynamic improvement.",
keywords = "Cardiogenic shock, Congestive heart failure, Phosphates, Skeletal muscle high energy, Skeletal muscle lactate",
author = "J. Karlsson and Willerson, {J. T.} and Leshin, {S. J.} and Mullins, {C. B.} and Mitchell, {J. H.}",
year = "1975",
doi = "10.1080/00365517509068008",
language = "English (US)",
volume = "35",
pages = "73--79",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
issn = "0036-5513",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Clinical physiology

T2 - Skeletal muscle metabolites in patients with cardiogenic shock or severe congestive heart failure

AU - Karlsson, J.

AU - Willerson, J. T.

AU - Leshin, S. J.

AU - Mullins, C. B.

AU - Mitchell, J. H.

PY - 1975

Y1 - 1975

N2 - Skeletal muscle metabolite concentrations were determined in 19 patients in either cardiogenic shock or severe left ventricular failure by obtaining a needle biopsy specimen of lateral thigh muscle. Evidence of anaerobic skeletal muscle metabolism was found in both patient groups with the greatest lactatc accumulation and most severe high-energy phosphate depletion present in the patients in cardiogenic shock. The skeletal muscle lactate accumulation was most pronounced in the patients that died. Blood lactate values did not absolutely predict skeletal muscle lactate concentrations in those patients in whom skeletal muscle lactate concentrations were the highest. The patients in cardiogenic shock and severe left ventricular failure who survived demonstrated a reduction in skeletal muscle lactate levels and a restoration of high-energy phosphates over several days which correlated with clinical and herno-dynamic improvement.

AB - Skeletal muscle metabolite concentrations were determined in 19 patients in either cardiogenic shock or severe left ventricular failure by obtaining a needle biopsy specimen of lateral thigh muscle. Evidence of anaerobic skeletal muscle metabolism was found in both patient groups with the greatest lactatc accumulation and most severe high-energy phosphate depletion present in the patients in cardiogenic shock. The skeletal muscle lactate accumulation was most pronounced in the patients that died. Blood lactate values did not absolutely predict skeletal muscle lactate concentrations in those patients in whom skeletal muscle lactate concentrations were the highest. The patients in cardiogenic shock and severe left ventricular failure who survived demonstrated a reduction in skeletal muscle lactate levels and a restoration of high-energy phosphates over several days which correlated with clinical and herno-dynamic improvement.

KW - Cardiogenic shock

KW - Congestive heart failure

KW - Phosphates

KW - Skeletal muscle high energy

KW - Skeletal muscle lactate

UR - http://www.scopus.com/inward/record.url?scp=0016611355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016611355&partnerID=8YFLogxK

U2 - 10.1080/00365517509068008

DO - 10.1080/00365517509068008

M3 - Article

C2 - 236594

AN - SCOPUS:0016611355

VL - 35

SP - 73

EP - 79

JO - Scandinavian Journal of Clinical and Laboratory Investigation

JF - Scandinavian Journal of Clinical and Laboratory Investigation

SN - 0036-5513

IS - 1

ER -